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Chemical Compound Review

Mycoside A     [29-[4-[4-[4-[5-acetyloxy-4- (4-hydroxy-5...

Synonyms: KST-1A0891, AC1L4XIL, AR-1A8835, AC1Q2W41
 
 
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Disease relevance of Mycoside A

  • A novel O-methyl-2,6-dideoxyhexose was isolated from the major phenolic glycolipid (previously called mycoside A) of Mycobacterium kansasii [1].
  • It was found that the antiserum immunoreacted with its homologous antigen but not with purified phenolic glycolipids from M. bovis BCG (mycoside B), M. kansasii (mycoside A), M. leprae (PGL-I) or M. marinum (mycoside G) [2].
 

High impact information on Mycoside A

  • Monocytes pretreated with dimycocerosyl phthiocerol, mycoside A of Mycobacterium kansasii, or mycoside B of Mycobacterium microti, on the other hand, released O2- in quantities comparable to control monocytes in response to M. leprae stimulation [3].
  • Peripheral blood monocytes were pretreated with phenolic glycolipid-I (PGL-I), dimycocerosyl phthiocerol (DIM), or mycoside A, then cultured in the presence or absence of interferon-gamma (IFN-gamma) [4].

References

  1. Structural elucidation of the major phenolic glycolipid from Mycobacterium kansasii. II. Presence of a novel dideoxyhexose. Fournié, J.J., Rivière, M., Papa, F., Puzo, G. J. Biol. Chem. (1987) [Pubmed]
  2. Specificity of Mycobacterium tuberculosis phenolic glycolipid (PGL-Tb1) antiserum. Papa, F., Laszlo, A., David, H.L. Ann. Inst. Pasteur Microbiol. (1988) [Pubmed]
  3. Suppression of monocyte oxidative response by phenolic glycolipid I of Mycobacterium leprae. Vachula, M., Holzer, T.J., Andersen, B.R. J. Immunol. (1989) [Pubmed]
  4. Effect of Mycobacterium leprae's phenolic glycolipid-I on interferon-gamma augmentation of monocyte oxidative responses. Vachula, M., Holzer, T.J., Kizlaitis, L., Andersen, B.R. Int. J. Lepr. Other Mycobact. Dis. (1990) [Pubmed]
 
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