Gene Review:
IFNG - interferon, gamma
Homo sapiens
Synonyms:
IFG, IFI, IFN-gamma, Immune interferon, Interferon gamma
- A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. An, P., Vlahov, D., Margolick, J.B., Phair, J., O'Brien, T.R., Lautenberger, J., O'Brien, S.J., Winkler, C.A. J. Infect. Dis. (2003)
- Linkage disequilibrium analysis of chromosome 12q14-15 in multiple sclerosis: delineation of a 118-kb interval around interferon-gamma (IFNG) that is involved in male versus female differential susceptibility. Goris, A., Heggarty, S., Marrosu, M.G., Graham, C., Billiau, A., Vandenbroeck, K. Genes Immun. (2002)
- Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. Nieters, A., Brems, S., Becker, N. Hum. Genet. (2001)
- Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting. Tiroch, K., von Beckerath, N., Koch, W., Lengdobler, J., Joost, A., Schömig, A., Kastrati, A. Atherosclerosis (2005)
- Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer. Saha, A., Dhir, A., Ranjan, A., Gupta, V., Bairwa, N., Bamezai, R. Immunogenetics (2005)
- How interferon-gamma keeps autoimmune diseases in check. Kelchtermans, H., Billiau, A., Matthys, P. Trends Immunol. (2008)
- Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Dimitrov, S., Lange, T., Tieken, S., Fehm, H.L., Born, J. Brain Behav. Immun. (2004)
- Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Rota, E., Bellone, G., Rocca, P., Bergamasco, B., Emanuelli, G., Ferrero, P. Neurol. Sci. (2006)
- Tumor necrosis factor-alpha: is there a continuum of liability between stress, anxiety states and anorexia nervosa? Holden, R.J., Pakula, I.S. Med. Hypotheses (1999)
- Suppression of cellular immunity in men with a past history of posttraumatic stress disorder. Kawamura, N., Kim, Y., Asukai, N. The American journal of psychiatry. (2001)
- Interferon gamma allelic variants: sex-biased multiple sclerosis susceptibility and gene expression. Kantarci, O.H., Hebrink, D.D., Schaefer-Klein, J., Sun, Y., Achenbach, S., Atkinson, E.J., Heggarty, S., Cotleur, A.C., de Andrade, M., Vandenbroeck, K., Pelfrey, C.M., Weinshenker, B.G. Arch. Neurol. (2008)
- Natural killer cells in antiviral defense: function and regulation by innate cytokines. Biron, C.A., Nguyen, K.B., Pien, G.C., Cousens, L.P., Salazar-Mather, T.P. Annu. Rev. Immunol. (1999)
- Cellular responses to interferon-gamma. Boehm, U., Klamp, T., Groot, M., Howard, J.C. Annu. Rev. Immunol. (1997)
- Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Constant, S.L., Bottomly, K. Annu. Rev. Immunol. (1997)
- Interferon gamma inhibits interleukin 10 production by monocytes. Chomarat, P., Rissoan, M.C., Banchereau, J., Miossec, P. J. Exp. Med. (1993)
- Dampening of IFN-{gamma}-Inducible Gene Expression in Human Choriocarcinoma Cells Is Due to Phosphatase-Mediated Inhibition of the JAK/STAT-1 Pathway. Choi, J.C., Holtz, R., Petroff, M.G., Alfaidy, N., Murphy, S.P. J. Immunol. (2007)
- Interleukin-1 inhibits gamma interferon-induced bacteriostasis in human uroepithelial cells. Däubener, W., Hucke, C., Seidel, K., Hadding, U., MacKenzie, C.R. Infect. Immun. (1999)
- Bacillus Calmette Guerin triggers the IL-12/IFN-gamma axis by an IRAK-4- and NEMO-dependent, non-cognate interaction between monocytes, NK, and T lymphocytes. Feinberg, J., Fieschi, C., Doffinger, R., Feinberg, M., Leclerc, T., Boisson-Dupuis, S., Picard, C., Bustamante, J., Chapgier, A., Filipe-Santos, O., Ku, C.L., de Beaucoudrey, L., Reichenbach, J., Antoni, G., Baldé, R., Alcaïs, A., Casanova, J.L. Eur. J. Immunol. (2004)
- Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis. Rieckmann, P., Weber, F., Günther, A., Martin, S., Bitsch, A., Broocks, A., Kitze, B., Weber, T., Börner, T., Poser, S. J. Neuroimmunol. (1996)
- IFN-gamma gene polymorphisms associate with development of EBV+ lymphoproliferative disease in hu PBL-SCID mice. Dierksheide, J.E., Baiocchi, R.A., Ferketich, A.K., Roychowdhury, S., Pelletier, R.P., Eisenbeis, C.F., Caligiuri, M.A., VanBuskirk, A.M. Blood (2005)
- MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. Horiuchi, M., Itoh, A., Pleasure, D., Itoh, T. J. Biol. Chem. (2006)
- Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. Morinobu, A., Kanno, Y., O'Shea, J.J. J. Biol. Chem. (2004)
- Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. Barnes, K.C., Freidhoff, L.R., Nickel, R., Chiu, Y.F., Juo, S.H., Hizawa, N., Naidu, R.P., Ehrlich, E., Duffy, D.L., Schou, C., Levett, P.N., Marsh, D.G., Beaty, T.H. J. Allergy Clin. Immunol. (1999)
- An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells. Gonsky, R., Deem, R.L., Bream, J.H., Young, H.A., Targan, S.R. Genes Immun. (2006)
- A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes. Jahromi, M., Millward, A., Demaine, A. J. Interferon Cytokine Res. (2000)
- Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Döcke, W.D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.D., Kox, W. Nat. Med. (1997)
- Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Watling, D., Guschin, D., Müller, M., Silvennoinen, O., Witthuhn, B.A., Quelle, F.W., Rogers, N.C., Schindler, C., Stark, G.R., Ihle, J.N. Nature (1993)
- Interleukin 8 (IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells. Kimata, H., Yoshida, A., Ishioka, C., Lindley, I., Mikawa, H. J. Exp. Med. (1992)
- Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. Penix, L., Weaver, W.M., Pang, Y., Young, H.A., Wilson, C.B. J. Exp. Med. (1993)
- Down-regulation of MHC II in mesenchymal stem cells at high IFN-gamma can be partly explained by cytoplasmic retention of CIITA. Tang, K.C., Trzaska, K.A., Smirnov, S.V., Kotenko, S.V., Schwander, S.K., Ellner, J.J., Rameshwar, P. J. Immunol. (2008)
- The extracellular domain of the human interferon gamma receptor interacts with a species-specific signal transducer. Gibbs, V.C., Williams, S.R., Gray, P.W., Schreiber, R.D., Pennica, D., Rice, G., Goeddel, D.V. Mol. Cell. Biol. (1991)
- Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor. Tsujimoto, M., Yip, Y.K., Vilcek, J. J. Immunol. (1986)
- A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. Bream, J.H., Hodge, D.L., Gonsky, R., Spolski, R., Leonard, W.J., Krebs, S., Targan, S., Morinobu, A., O'Shea, J.J., Young, H.A. J. Biol. Chem. (2004)
- Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes. Donnelly, R.P., Freeman, S.L., Hayes, M.P. J. Immunol. (1995)
- IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma. Veenstra, K.G., Jonak, Z.L., Trulli, S., Gollob, J.A. J. Immunol. (2002)
- Interferon-gamma-induced JAK2 and STAT1 signalling in a human salivary gland cell line. Wu, A.J., Chen, Z.J., Kan, E.C., Baum, B.J. J. Cell. Physiol. (1997)
- IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Elser, B., Lohoff, M., Kock, S., Giaisi, M., Kirchhoff, S., Krammer, P.H., Li-Weber, M. Immunity (2002)
- Regulation of cytokine production by soluble CD23: costimulation of interferon gamma secretion and triggering of tumor necrosis factor alpha release. Armant, M., Ishihara, H., Rubio, M., Delespesse, G., Sarfati, M. J. Exp. Med. (1994)
- Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma. Lu, H.T., Riley, J.L., Babcock, G.T., Huston, M., Stark, G.R., Boss, J.M., Ransohoff, R.M. J. Exp. Med. (1995)
- Apical role for BRG1 in cytokine-induced promoter assembly. Ni, Z., Karaskov, E., Yu, T., Callaghan, S.M., Der, S., Park, D.S., Xu, Z., Pattenden, S.G., Bremner, R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression. Geraghty, P., Greene, C.M., O'Mahony, M., O'Neill, S.J., Taggart, C.C., McElvaney, N.G. J. Biol. Chem. (2007)
- Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. Cuffy, M.C., Silverio, A.M., Qin, L., Wang, Y., Eid, R., Brandacher, G., Lakkis, F.G., Fuchs, D., Pober, J.S., Tellides, G. J. Immunol. (2007)
- Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells. Hastie, C., Masters, J.R., Moss, S.E., Naaby-Hansen, S. J. Biol. Chem. (2008)
- Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma. Kondadasula, S.V., Roda, J.M., Parihar, R., Yu, J., Lehman, A., Caligiuri, M.A., Tridandapani, S., Burry, R.W., Carson, W.E. Blood (2008)
- Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Shuai, K., Ziemiecki, A., Wilks, A.F., Harpur, A.G., Sadowski, H.B., Gilman, M.Z., Darnell, J.E. Nature (1993)
- Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. Larner, A.C., David, M., Feldman, G.M., Igarashi, K., Hackett, R.H., Webb, D.S., Sweitzer, S.M., Petricoin, E.F., Finbloom, D.S. Science (1993)
- Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis. Alvaro-Gracia, J.M., Zvaifler, N.J., Firestein, G.S. J. Exp. Med. (1989)
- Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells. Karray, S., DeFrance, T., Merle-Béral, H., Banchereau, J., Debré, P., Galanaud, P. J. Exp. Med. (1988)
- IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB. Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., Samten, B., García, V.E. J. Infect. Dis. (2009)
- Evidence that interferon-gamma plays a protective role during cerebral malaria. Cabantous, S., Poudiougou, B., Traore, A., Keita, M., Cisse, M.B., Doumbo, O., Dessein, A.J., Marquet, S. J. Infect. Dis. (2005)
- Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region. Koch, O., Rockett, K., Jallow, M., Pinder, M., Sisay-Joof, F., Kwiatkowski, D. Genes Immun. (2005)
- The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility. Wapenaar, M.C., van Belzen, M.J., Fransen, J.H., Sarasqueta, A.F., Houwen, R.H., Meijer, J.W., Mulder, C.J., Wijmenga, C. J. Autoimmun. (2004)
- Detection of DNA abnormalities by arbitrarily primed PCR fingerprinting: amplification of the MDM2 gene in a mediastinum fibrosarcoma. Kuchiki, H., Yasuda, J., Kayama, T., Murakami, Y., Sekiya, T. Biochem. Biophys. Res. Commun. (1999)