Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Actinium-225 actinium

Synonyms: AC1L4Z7V, 225Ac, 14265-85-1, Actinium, isotope of mass 225

Ballangrud, A.M. et al., Jurcic, J.G., Deal, K.A. et al., Borchardt, P.E. et al.

Jurcic,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of actinium

Targeted actinium-225 in vivo generators for therapy of ovarian cancer [1].
The objective of this study was to investigate the efficacy of trastuzumab labeled with the alpha-particle emitting atomic generator, actinium-225 ((225)Ac), against breast cancer spheroids with different HER2/neu expression levels [2].

High impact information on actinium

Conversely, a-particle immunotherapy with isotopes such as bismuth-213 or actinium-225 offers the possibility of selective tumor cell kill while sparing surrounding normal tissues [3].

Analytical, diagnostic and therapeutic context of actinium

The favorable nuclear properties of actinium-225 ((225)Ac) have led to proposal of this isotope for use in radioimmunotherapy [4].

References

Targeted actinium-225 in vivo generators for therapy of ovarian cancer. Borchardt, P.E., Yuan, R.R., Miederer, M., McDevitt, M.R., Scheinberg, D.A. Cancer Res. (2003) [Pubmed]
Alpha-particle emitting atomic generator (Actinium-225)-labeled trastuzumab (herceptin) targeting of breast cancer spheroids: efficacy versus HER2/neu expression. Ballangrud, A.M., Yang, W.H., Palm, S., Enmon, R., Borchardt, P.E., Pellegrini, V.A., McDevitt, M.R., Scheinberg, D.A., Sgouros, G. Clin. Cancer Res. (2004) [Pubmed]
Immunotherapy for acute myeloid leukemia. Jurcic, J.G. Current oncology reports. (2005) [Pubmed]
Improved in vivo stability of actinium-225 macrocyclic complexes. Deal, K.A., Davis, I.A., Mirzadeh, S., Kennel, S.J., Brechbiel, M.W. J. Med. Chem. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.