Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

N3-dU 1-[(2R,3R,4S,5R)-3-azido-4- hydroxy-5...

Synonyms: AG-E-85348, KB-20896, CTK4F8749, HG1151, AR-1D8987, ...

Kang, S.H. et al., Roy, B. et al., Salowe, S. et al.

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Disease relevance of EINECS 248-113-6

Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate [1].

High impact information on EINECS 248-113-6

The interaction of the beta-d and beta-l stereoisomers of 2'-azido-2'-deoxyuridine 5'-diphosphate with purified Escherichia coli RNR was also examined [2].
It characterizes the phosphorylation steps involved in the conversion of 2'-azido-2'-deoxyuridine (N3Urd) and 2'-azido-2'-deoxycytidine (N3Cyd) to the corresponding diphosphates and explores a prodrug approach in cellular delivery of the inhibitor which circumvents the requirement of deoxynucleoside kinases [3].

References

Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2'-azido-2'-deoxyuridine 5'-diphosphate. Salowe, S., Bollinger, J.M., Ator, M., Stubbe, J., McCraken, J., Peisach, J., Samano, M.C., Robins, M.J. Biochemistry (1993) [Pubmed]
Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides. Roy, B., Verri, A., Lossani, A., Spadari, S., Focher, F., Aubertin, A.M., Gosselin, G., Mathé, C., Périgaud, C. Biochem. Pharmacol. (2004) [Pubmed]
Cellular delivery of nucleoside diphosphates: a prodrug approach. Kang, S.H., Sinhababu, A.K., Cory, J.G., Mitchell, B.S., Thakker, D.R., Cho, M.J. Pharm. Res. (1997) [Pubmed]

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