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Chemical Compound Review:

NSC-678532 4-amino-1-[3-azido-4-hydroxy- 5...

Synonyms: AC1L8RTJ, CTK8I9465, NSC678532, AR-1G0442, AC1Q6C3F, ...

Kang, S.H. et al., Giacca, M. et al., Bianchi, V. et al., Kang, S.H. et al., Sjöberg, B.M. et al.

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Disease relevance of NSC678532

In the reaction between bacteriophage T4 ribonucleotide reductase and 2'-azido-2'-deoxycytidine 5'-diphosphate an identical nucleotide radical is formed [1].

High impact information on NSC678532

After phosphorylation to the corresponding diphosphates, 2'-azido-2'-deoxycytidine and 2'-difluorocytidine act as powerful inhibitors of ribonucleotide reductase [2].
Treatment with low doses of AZT (0.05-0.1 microM) and either hydroxyurea (25-100 microM) or 2'-azido-2'-deoxycytidine (0.25-4 microM) lasted 2 weeks, during which p24 in the culture medium was monitored [3].
The prodrug was evaluated for cell growth inhibition against a variety of tumor cell lines along with 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine [4].
2'-Azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine were evaluated for their inhibitory activity against ribonucleotide reductase and for subsequent cell growth inhibition [5].

Associations of NSC678532 with other chemical compounds

Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine [5].

References

A substrate radical intermediate in the reaction between ribonucleotide reductase from Escherichia coli and 2'-azido-2'-deoxynucleoside diphosphates. Sjöberg, B.M., Gräslund, A., Eckstein, F. J. Biol. Chem. (1983) [Pubmed]
Inhibition of ribonucleotide reductase by 2'-substituted deoxycytidine analogs: possible application in AIDS treatment. Bianchi, V., Borella, S., Calderazzo, F., Ferraro, P., Chieco Bianchi, L., Reichard, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Synergistic antiviral action of ribonucleotide reductase inhibitors and 3'-azido-3'-deoxythymidine on HIV type 1 infection in vitro. Giacca, M., Borella, S., Calderazzo, F., Bianchi, L.C., D'Agaro, P., Rampazzo, C., Bianchi, V., Reichard, P. AIDS Res. Hum. Retroviruses (1996) [Pubmed]
Synthesis and biological activity of bis(pivaloyloxymethyl) ester of 2'-azido-2'-deoxyuridine 5'-monophosphate. Kang, S.H., Sinhababu, A.K., Cho, M.J. Nucleosides Nucleotides (1998) [Pubmed]
Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine. Kang, S.H., Cho, M.J. Nucleosides Nucleotides (1998) [Pubmed]

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