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Chemical Compound Review

AC1L423P     praseodymium

Synonyms: 136Pr, 22095-53-0, Praseodymium-136, Praseodymium, isotope of mass 136
 
 
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Disease relevance of praseodymium

  • (3) Severe hepatotoxicity was observed after administration of Ce and Pr; fatty liver, jaundice, and elevated serum GOT and GPT levels were most prominent on Day 3 [1].
 

High impact information on praseodymium

  • Pr3+ is shown to be a good analog for calcium binding to the high affinity sites on the enzyme since it competitively displaces calcium, as evidenced by the reversal of the specific calcium-dependent intrinsic fluorescent signal and inactivation of ATPase activity, over the same narrow range in Pr3+ concentration where energy transfer is observed [2].
  • Praseodymium ion (Pr3+) produces the same protective effect in liver tissue cultures [3].

References

  1. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. Nakamura, Y., Tsumura, Y., Tonogai, Y., Shibata, T., Ito, Y. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
  2. Localization of site-specific probes on the Ca-ATPase of sarcoplasmic reticulum using fluorescence energy transfer. Squier, T.C., Bigelow, D.J., Garcia de Ancos, J., Inesi, G. J. Biol. Chem. (1987) [Pubmed]
  3. Toxicological and cytophysiological aspects of lanthanides action. Pałasz, A., Czekaj, P. Acta Biochim. Pol. (2000) [Pubmed]
 
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