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Chemical Compound Review

AC1L423P     praseodymium

Synonyms: 136Pr, 22095-53-0, Praseodymium-136, Praseodymium, isotope of mass 136
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Disease relevance of praseodymium

  • (3) Severe hepatotoxicity was observed after administration of Ce and Pr; fatty liver, jaundice, and elevated serum GOT and GPT levels were most prominent on Day 3 [1].

High impact information on praseodymium

  • Pr3+ is shown to be a good analog for calcium binding to the high affinity sites on the enzyme since it competitively displaces calcium, as evidenced by the reversal of the specific calcium-dependent intrinsic fluorescent signal and inactivation of ATPase activity, over the same narrow range in Pr3+ concentration where energy transfer is observed [2].
  • Praseodymium ion (Pr3+) produces the same protective effect in liver tissue cultures [3].


  1. Differences in behavior among the chlorides of seven rare earth elements administered intravenously to rats. Nakamura, Y., Tsumura, Y., Tonogai, Y., Shibata, T., Ito, Y. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
  2. Localization of site-specific probes on the Ca-ATPase of sarcoplasmic reticulum using fluorescence energy transfer. Squier, T.C., Bigelow, D.J., Garcia de Ancos, J., Inesi, G. J. Biol. Chem. (1987) [Pubmed]
  3. Toxicological and cytophysiological aspects of lanthanides action. Pałasz, A., Czekaj, P. Acta Biochim. Pol. (2000) [Pubmed]
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