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MeSH Review

Fatty Liver

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Disease relevance of Fatty Liver


Psychiatry related information on Fatty Liver

  • To assess whether this phospholipid also affects earlier changes induced by alcohol consumption (such as fatty liver and hyperlipemia), 28 male rat littermates were pair-fed liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 21 d, and killed 90 min after intragastric administration of the corresponding diets [6].
  • Acetaldehyde at 1 to 6 micromolar concentration in the blood and tissues of alcoholics cannot account for the extent of tissue damage, nor can it adequately explain liver steatosis characterized by accumulation of cholesterol and fatty acids and their esters in the liver of alcoholics known for their poor dietary habits [7].

High impact information on Fatty Liver


Chemical compound and disease context of Fatty Liver


Biological context of Fatty Liver

  • Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes [13].
  • Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met [17].
  • 6 of the babies had long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) deficiency, and each of the pregnancies was complicated by features such as fatty liver and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome [18].
  • BACKGROUND & AIMS: Profound impairment of liver regeneration in rodents with dysfunctional leptin signaling has been attributed to non-alcohol-induced fatty liver disorders (NAFLD) [19].
  • Transgenes consisting of segments of the rat liver fatty acid-binding protein (L-FABP) gene's 5' non-transcribed domain linked to the human growth hormone (hGH) gene (minus its regulatory elements) have provided useful tools for analyzing the mechanisms that regulate cellular and spatial differentiation of the continuously renewing gut epithelium [20].

Anatomical context of Fatty Liver


Gene context of Fatty Liver


Analytical, diagnostic and therapeutic context of Fatty Liver


  1. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Lin, H.Z., Yang, S.Q., Chuckaree, C., Kuhajda, F., Ronnet, G., Diehl, A.M. Nat. Med. (2000) [Pubmed]
  2. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. Cortez-Pinto, H., Chatham, J., Chacko, V.P., Arnold, C., Rashid, A., Diehl, A.M. JAMA (1999) [Pubmed]
  3. Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes. Matern, S., Matern, H., Farthmann, E.H., Gerok, W. J. Clin. Invest. (1984) [Pubmed]
  4. Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease. Ioannou, G.N., Weiss, N.S., Boyko, E.J., Kahn, S.E., Lee, S.P. Gastroenterology (2005) [Pubmed]
  5. Effect of an intravenous infusion of ethanol on serum enzymes and lipids in patients with alcoholic liver disease. Nishimura, M., Hasumura, Y., Takeuchi, J. Gastroenterology (1980) [Pubmed]
  6. Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. Navder, K.P., Baraona, E., Lieber, C.S. J. Nutr. (1997) [Pubmed]
  7. Oxysterols and alcoholic liver disease. Ryzlak, M.T., Fales, H.M., Russell, W.L., Schaffner, C.P. Alcohol. Clin. Exp. Res. (1990) [Pubmed]
  8. TNF-alpha is not the cause of fatty liver disease in obese diabetic mice. Memon, R.A., Grunfeld, C., Feingold, K.R. Nat. Med. (2001) [Pubmed]
  9. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Shimomura, I., Hammer, R.E., Richardson, J.A., Ikemoto, S., Bashmakov, Y., Goldstein, J.L., Brown, M.S. Genes Dev. (1998) [Pubmed]
  10. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes. Sweetser, D.A., Birkenmeier, E.H., Hoppe, P.C., McKeel, D.W., Gordon, J.I. Genes Dev. (1988) [Pubmed]
  11. Farnesoid X receptor is essential for normal glucose homeostasis. Ma, K., Saha, P.K., Chan, L., Moore, D.D. J. Clin. Invest. (2006) [Pubmed]
  12. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. Donnelly, K.L., Smith, C.I., Schwarzenberg, S.J., Jessurun, J., Boldt, M.D., Parks, E.J. J. Clin. Invest. (2005) [Pubmed]
  13. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. Matsusue, K., Haluzik, M., Lambert, G., Yim, S.H., Gavrilova, O., Ward, J.M., Brewer, B., Reitman, M.L., Gonzalez, F.J. J. Clin. Invest. (2003) [Pubmed]
  14. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Cope, K., Risby, T., Diehl, A.M. Gastroenterology (2000) [Pubmed]
  15. Fatty liver induced by tetracycline in the rat. Dose-response relationships and effect of sex. Breen, K.J., Schenker, S., Heimberg, M. Gastroenterology (1975) [Pubmed]
  16. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. Rivera, C.A., Adegboyega, P., van Rooijen, N., Tagalicud, A., Allman, M., Wallace, M. J. Hepatol. (2007) [Pubmed]
  17. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., Ishii, H. Gastroenterology (2004) [Pubmed]
  18. Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency. Wilcken, B., Leung, K.C., Hammond, J., Kamath, R., Leonard, J.V. Lancet (1993) [Pubmed]
  19. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Leclercq, I.A., Field, J., Farrell, G.C. Gastroenterology (2003) [Pubmed]
  20. Epithelial cell differentiation in normal and transgenic mouse intestinal isografts. Rubin, D.C., Roth, K.A., Birkenmeier, E.H., Gordon, J.I. J. Cell Biol. (1991) [Pubmed]
  21. Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats. Tahara, M., Matsumoto, K., Nukiwa, T., Nakamura, T. J. Clin. Invest. (1999) [Pubmed]
  22. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Li, Z., Lin, H., Yang, S., Diehl, A.M. Gastroenterology (2002) [Pubmed]
  23. Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants. Roth, K.A., Hermiston, M.L., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  24. Normal hepatocytes exhibiting histone H3 with antibody accessible sites that are cryptic in carcinogen-altered hepatocytes. Munir, K.M., Custer, R.P., Sorof, S. Cancer Res. (1989) [Pubmed]
  25. Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver. Romics, L., Kodys, K., Dolganiuc, A., Graham, L., Velayudham, A., Mandrekar, P., Szabo, G. Hepatology (2004) [Pubmed]
  26. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A.A., Kahn, C.R., Ntambi, J.M., Socci, N.D., Friedman, J.M. J. Clin. Invest. (2004) [Pubmed]
  27. Selective deletion of leptin receptor in neurons leads to obesity. Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Mombaerts, P., Friedman, J.M. J. Clin. Invest. (2001) [Pubmed]
  28. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. McMullen, M.R., Pritchard, M.T., Wang, Q., Millward, C.A., Croniger, C.M., Nagy, L.E. Gastroenterology (2005) [Pubmed]
  29. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W.P., Kim, Y.J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M.A., Wu, H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T.A., Xu, H., Ortegon, A.M., Kazantzis, M., Kay, M.A., Stahl, A. J. Biol. Chem. (2008) [Pubmed]
  31. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. Wei, Y., Clark, S.E., Morris, E.M., Thyfault, J.P., Uptergrove, G.M., Whaley-Connell, A.T., Ferrario, C.M., Sowers, J.R., Ibdah, J.A. J. Hepatol. (2008) [Pubmed]
  32. Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome. Abid, A., Taha, O., Nseir, W., Farah, R., Grosovski, M., Assy, N. J. Hepatol. (2009) [Pubmed]
  33. Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation. Da Silva Morais, A., Lebrun, V., Abarca-Quinones, J., Brichard, S., Hue, L., Guigas, B., Viollet, B., Leclercq, I.A. J. Hepatol. (2009) [Pubmed]
  34. Differential diagnosis between non-A, non-B hepatitis and fatty liver by measurement of urinary neopterin. Reibnegger, G., Judmaier, G., Wachter, H. Lancet (1988) [Pubmed]
  35. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hong, F., Radaeva, S., Pan, H.N., Tian, Z., Veech, R., Gao, B. Hepatology (2004) [Pubmed]
  36. Subunits of fatty acid synthetase complexes. Enzymatic activities and properties of the half-molecular weight nonidentical subunits of pigeon liver fatty acid synthetase. Lornitzo, F.A., Qureshi, A.A., Porter, J.W. J. Biol. Chem. (1975) [Pubmed]
  37. Evidence for a role of the gut hormone PYY in the regulation of intestinal fatty acid-binding protein transcripts in differentiated subpopulations of intestinal epithelial cell hybrids. Halldén, G., Aponte, G.W. J. Biol. Chem. (1997) [Pubmed]
  38. Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects. Holt, H.B., Wild, S.H., Wood, P.J., Zhang, J., Darekar, A.A., Dewbury, K., Poole, R.B., Holt, R.I., Phillips, D.I., Byrne, C.D. Diabetologia (2006) [Pubmed]
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