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MeSH Review

Fatty Liver

 
 
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Disease relevance of Fatty Liver

 

Psychiatry related information on Fatty Liver

  • To assess whether this phospholipid also affects earlier changes induced by alcohol consumption (such as fatty liver and hyperlipemia), 28 male rat littermates were pair-fed liquid diets containing 36% of energy either as ethanol or as additional carbohydrate for 21 d, and killed 90 min after intragastric administration of the corresponding diets [6].
  • Acetaldehyde at 1 to 6 micromolar concentration in the blood and tissues of alcoholics cannot account for the extent of tissue damage, nor can it adequately explain liver steatosis characterized by accumulation of cholesterol and fatty acids and their esters in the liver of alcoholics known for their poor dietary habits [7].
 

High impact information on Fatty Liver

 

Chemical compound and disease context of Fatty Liver

 

Biological context of Fatty Liver

  • Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes [13].
  • Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met [17].
  • 6 of the babies had long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) deficiency, and each of the pregnancies was complicated by features such as fatty liver and HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome [18].
  • BACKGROUND & AIMS: Profound impairment of liver regeneration in rodents with dysfunctional leptin signaling has been attributed to non-alcohol-induced fatty liver disorders (NAFLD) [19].
  • Transgenes consisting of segments of the rat liver fatty acid-binding protein (L-FABP) gene's 5' non-transcribed domain linked to the human growth hormone (hGH) gene (minus its regulatory elements) have provided useful tools for analyzing the mechanisms that regulate cellular and spatial differentiation of the continuously renewing gut epithelium [20].
 

Anatomical context of Fatty Liver

 

Gene context of Fatty Liver

 

Analytical, diagnostic and therapeutic context of Fatty Liver

References

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  8. TNF-alpha is not the cause of fatty liver disease in obese diabetic mice. Memon, R.A., Grunfeld, C., Feingold, K.R. Nat. Med. (2001) [Pubmed]
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  13. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. Matsusue, K., Haluzik, M., Lambert, G., Yim, S.H., Gavrilova, O., Ward, J.M., Brewer, B., Reitman, M.L., Gonzalez, F.J. J. Clin. Invest. (2003) [Pubmed]
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  17. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M., Ishii, H. Gastroenterology (2004) [Pubmed]
  18. Pregnancy and fetal long-chain 3-hydroxyacyl coenzyme A dehydrogenase deficiency. Wilcken, B., Leung, K.C., Hammond, J., Kamath, R., Leonard, J.V. Lancet (1993) [Pubmed]
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  20. Epithelial cell differentiation in normal and transgenic mouse intestinal isografts. Rubin, D.C., Roth, K.A., Birkenmeier, E.H., Gordon, J.I. J. Cell Biol. (1991) [Pubmed]
  21. Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats. Tahara, M., Matsumoto, K., Nukiwa, T., Nakamura, T. J. Clin. Invest. (1999) [Pubmed]
  22. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Li, Z., Lin, H., Yang, S., Diehl, A.M. Gastroenterology (2002) [Pubmed]
  23. Use of transgenic mice to infer the biological properties of small intestinal stem cells and to examine the lineage relationships of their descendants. Roth, K.A., Hermiston, M.L., Gordon, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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  28. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. McMullen, M.R., Pritchard, M.T., Wang, Q., Millward, C.A., Croniger, C.M., Nagy, L.E. Gastroenterology (2005) [Pubmed]
  29. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W.P., Kim, Y.J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M.A., Wu, H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T.A., Xu, H., Ortegon, A.M., Kazantzis, M., Kay, M.A., Stahl, A. J. Biol. Chem. (2008) [Pubmed]
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