Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Mycosamin (2S,3S,4S,5R)-3-amino-2,4,5- trihydroxy...

Synonyms: Mycosamine, CHEBI:32570, AC1L4AAB, CTK1C3857, 527-38-8, ...

Byrne, B. et al., Caffrey, P. et al., Raatikainen, O. et al., Tweit, R.C. et al.

Caffrey, Lynch, Flood, Finnan, Oliynyk,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Mycosamin

Analysis of products by mass spectrometry and NMR indicated that the amphDIII mutant produced 8-deoxyamphoteronolides A and B. This suggests that glycosylation with mycosamine normally precedes C-8 hydroxylation and that formation of the exocyclic carboxyl group can occur prior to both these modifications [1].
Nucleotide sequence analysis of 113193 bp of this region revealed six large polyketide synthase genes as well as genes for two cytochrome P450 enzymes, two ABC transporter proteins, and genes involved in biosynthesis and attachment of mycosamine [2].
Both partricins A and B yield mycosamine on mild acid hydrolysis [3].

Analytical, diagnostic and therapeutic context of Mycosamin

Identification of aromatic moieties and mycosamine in antifungal heptaenes with high-performance liquid chromatography, high-performance liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry [4].

References

Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus. Byrne, B., Carmody, M., Gibson, E., Rawlings, B., Caffrey, P. Chem. Biol. (2003) [Pubmed]
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes. Caffrey, P., Lynch, S., Flood, E., Finnan, S., Oliynyk, M. Chem. Biol. (2001) [Pubmed]
Characterization of the antifungal and antiprotozoal antibiotic partricin and structural studies on partricins A and B. Tweit, R.C., Pandey, R.C., Rinehart, K.L. J. Antibiot. (1982) [Pubmed]
Identification of aromatic moieties and mycosamine in antifungal heptaenes with high-performance liquid chromatography, high-performance liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Raatikainen, O., Auriola, S., Tuomisto, J. J. Chromatogr. (1991) [Pubmed]

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