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Chemical Compound Review:

SureCN4735302 [(3S,8S,9S,10R,13R,14S,17R)- 10,13-dimethyl...

Synonyms: AR-1I2184, AC1L4P9X, Cholesteryl lignocerate, Cholesteryl tetracosanoate, Cholest-5-en-3-ol (3beta)-, tetracosanoate

Michels, V.V. et al., Ginsburg, G.S. et al.

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Disease relevance of Cholesteryl lignocerate

Cholesteryl lignocerate hydrolysis was deficient in cells from patients with cholesteryl ester storage disease or Wolman disease due to acid lipase deficiency, but was in the control range for adrenoleukodystrophy fibroblasts [1].

High impact information on Cholesteryl lignocerate

This suggests that cholesteryl lignocerate hydrolysis can be carried out by acid lipase [1].
Cholesteryl lignocerate hydrolysis in adrenoleukodystrophy [1].
Significantly, the addition of a single double bond to the acyl chain of a fully saturated cholesteryl ester which exhibits no mesophases (e.g., cholesteryl behenate (C22:0) and cholesteryl lignocerate (C24:0) yields an ester which displays an unusually stable smectic mesophase, bot no cholesteric mesophase [2].

References

Cholesteryl lignocerate hydrolysis in adrenoleukodystrophy. Michels, V.V., Beaudet, A.L. Pediatr. Res. (1980) [Pubmed]
Physical properties of cholesteryl esters having 20 carbons or more. Ginsburg, G.S., Small, D.M. Biochim. Biophys. Acta (1981) [Pubmed]

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