Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Ala-phosphate [(2R)-2- aminopropanoyl]oxyphosphonic acid

Synonyms: AG-K-50116, KST-1A1570, CTK4B6012, AR-1A2694, AC1L508S, ...

Healy, V.L. et al., Greenlee, W.J. et al.

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Disease relevance of alanyloxyphosphonic acid

Here we have compared these with the Escherichia coli D-Ala-D-Ala ligase DdlB for formation of the enzyme-bound D-alanyl phosphate, D-Ala(1)-PO(3)(2-) (D-Ala(1)-P), intermediate [1].

High impact information on alanyloxyphosphonic acid

With tabtoxinine, a potent inhibitor of glutamine synthetase, as a model, beta-lactams 9R and 9S were synthesized as potential precursors of a D-alanyl phosphate mimic [2].

References

D-Ala-D-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies. Healy, V.L., Mullins, L.S., Li, X., Hall, S.E., Raushel, F.M., Walsh, C.T. Chem. Biol. (2000) [Pubmed]
Synthesis of an analogue of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming). Greenlee, W.J., Springer, J.P., Patchett, A.A. J. Med. Chem. (1989) [Pubmed]

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