Chemical Compound Review:
Dialanine 2-(2- aminopropanoylamino)propanoic acid
Synonyms:
Alanylalanine, Ala-ala, Di-L-Alanine, DL-Ala-DL-Ala, CHEMBL52461, ...
- Tertiary structural similarity between a class A beta-lactamase and a penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase. Samraoui, B., Sutton, B.J., Todd, R.J., Artymiuk, P.J., Waley, S.G., Phillips, D.C. Nature (1986)
- Phosphinate analogs of D-, D-dipeptides: slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium. Wu, Z., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1995)
- VanX, a bacterial D-alanyl-D-alanine dipeptidase: resistance, immunity, or survival function? Lessard, I.A., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine. Noda, M., Kawahara, Y., Ichikawa, A., Matoba, Y., Matsuo, H., Lee, D.G., Kumagai, T., Sugiyama, M. J. Biol. Chem. (2004)
- Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase. Mullins, L.S., Zawadzke, L.E., Walsh, C.T., Raushel, F.M. J. Biol. Chem. (1990)
- Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine. Sheldrick, G.M., Jones, P.G., Kennard, O., Williams, D.H., Smith, G.A. Nature (1978)
- The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance. Bussiere, D.E., Pratt, S.D., Katz, L., Severin, J.M., Holzman, T., Park, C.H. Mol. Cell (1998)
- Genes for the peptidoglycan synthesis pathway are essential for chloroplast division in moss. Machida, M., Takechi, K., Sato, H., Chung, S.J., Kuroiwa, H., Takio, S., Seki, M., Shinozaki, K., Fujita, T., Hasebe, M., Takano, H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Swiveling-domain mechanism for enzymatic phosphotransfer between remote reaction sites. Herzberg, O., Chen, C.C., Kapadia, G., McGuire, M., Carroll, L.J., Noh, S.J., Dunaway-Mariano, D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Role of Ser-238 and Lys-240 in the hydrolysis of third-generation cephalosporins by SHV-type beta-lactamases probed by site-directed mutagenesis and three-dimensional modeling. Huletsky, A., Knox, J.R., Levesque, R.C. J. Biol. Chem. (1993)
- Mechanisms and implications of glycopeptide resistance in enterococci. Derlot, E., Courvalin, P. Am. J. Med. (1991)
- Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B. Park, I.S., Lin, C.H., Walsh, C.T. Biochemistry (1996)
- Partial purification and specificity studies of the D-glutamate-adding and D-alanyl-D-alanine-adding enzymes from Escherichia coli K12. Michaud, C., Blanot, D., Flouret, B., Van Heijenoort, J. Eur. J. Biochem. (1987)
- Altering enzymatic activity: recruitment of carboxypeptidase activity into an RTEM beta-lactamase/penicillin-binding protein 5 chimera. Chang, Y.H., Labgold, M.R., Richards, J.H. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Peptidoglycan amidase MepA is a LAS metallopeptidase. Marcyjaniak, M., Odintsov, S.G., Sabala, I., Bochtler, M. J. Biol. Chem. (2004)
- D-Alanyl-D-lactate and D-alanyl-D-alanine synthesis by D-alanyl-D-alanine ligase from vancomycin-resistant Leuconostoc mesenteroides. Effects of a phenylalanine 261 to tyrosine mutation. Park, I.S., Walsh, C.T. J. Biol. Chem. (1997)
- Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Arthur, M., Depardieu, F., Reynolds, P., Courvalin, P. Mol. Microbiol. (1996)
- Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes. Ghuysen, J.M., Frère, J.M., Leyh-Bouille, M., Nguyen-Distèche, M., Coyette, J. Biochem. J. (1986)
- Alanine enhances jejunal sodium absorption in the presence of glucose: studies in piglet viral diarrhea. Rhoads, J.M., MacLeod, R.J., Hamilton, J.R. Pediatr. Res. (1986)
- Comparative proteomic analysis of Staphylococcus aureus strains with differences in resistance to the cell wall-targeting antibiotic vancomycin. Pieper, R., Gatlin-Bunai, C.L., Mongodin, E.F., Parmar, P.P., Huang, S.T., Clark, D.J., Fleischmann, R.D., Gill, S.R., Peterson, S.N. Proteomics (2006)
- The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. Hong, H.J., Hutchings, M.I., Hill, L.M., Buttner, M.J. J. Biol. Chem. (2005)
- Inducible carboxypeptidase activity in vancomycin-resistant enterococci. Gutmann, L., Billot-Klein, D., al-Obeid, S., Klare, I., Francoual, S., Collatz, E., van Heijenoort, J. Antimicrob. Agents Chemother. (1992)
- Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities. Janowiak, B.E., Griffith, O.W. J. Biol. Chem. (2005)
- Gamma-glutamylcysteine synthetase-glutathione synthetase: domain structure and identification of residues important in substrate and glutathione binding. Janowiak, B.E., Hayward, M.A., Peterson, F.C., Volkman, B.F., Griffith, O.W. Biochemistry (2006)
- The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta). Pastorino, L., Ikin, A.F., Nairn, A.C., Pursnani, A., Buxbaum, J.D. Mol. Cell. Neurosci. (2002)
- Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-gamma-glutamate ligases: identification of a ligase superfamily. Eveland, S.S., Pompliano, D.L., Anderson, M.S. Biochemistry (1997)
- Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivity. McCoy, A.J., Maurelli, A.T. Mol. Microbiol. (2005)
- Crystallographic mapping of beta-lactams bound to a D-alanyl-D-alanine peptidase target enzyme. Kelly, J.A., Knox, J.R., Zhao, H., Frère, J.M., Ghaysen, J.M. J. Mol. Biol. (1989)
- On-column derivatization of the antibiotics teicoplanin and ristocetin coupled to affinity capillary electrophoresis. Silverio, C.F., Azad, M., Gomez, F.A. Electrophoresis (2003)
- Antibodies to peptidoglycan in patients with spondylarthritis: a clue to disease aetiology? Park, H., Schumacher, H.R., Zeiger, A.R., Rosenbaum, J.T. Ann. Rheum. Dis. (1984)
- Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada. Boyd, D.A., Conly, J., Dedier, H., Peters, G., Robertson, L., Slater, E., Mulvey, M.R. J. Clin. Microbiol. (2000)
- Resistance to cefotaxime and peptidoglycan composition in Enterococcus faecalis are influenced by exogenous sodium chloride. Mainardi, J.L., Billot-Klein, D., Coutrot, A., Legrand, R., Schoot, B., Gutmann, L. Microbiology (Reading, Engl.) (1998)