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Chemical Compound Review:

Aminohexane [2-(dimethylaminomethyl)-1- ethyl...

Synonyms: LS-57101, CTK8J5147, BRN 3341959, AC1L46FA, 5959-44-4, ...

Filipponi, P. et al., O'Rourke, N.P. et al., Delmas, P.D. et al.

Filipponi, Cristallini, Policani, Casciari, Gregorio,

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Disease relevance of Aminohexane

This study assessed the efficacy of 200 mg of aminohexane bisphosphonate (neridronate) administered by intravenous infusion in a single dose or in two separate doses on consecutive days in 32 patients (16 males and 16 females, average age 66 years) affected by active Paget's disease of bone [1].
We conclude that aminohexane bisphosphonate is an effective agent in the treatment of tumour-induced hypercalcaemia, with rapid onset of effect and low toxicity [2].

High impact information on Aminohexane

Two patients had a relapse 14 to 16 months after treatment, and received a second course of aminohexane diphosphonate with the same efficacy [3].

References

Paget's disease of bone: benefits of neridonate as a first treatment and in cases of relapse after clodronate. Filipponi, P., Cristallini, S., Policani, G., Casciari, C., Gregorio, F. Bone (1998) [Pubmed]
Treatment of malignant hypercalcaemia with aminohexane bisphosphonate (neridronate). O'Rourke, N.P., McCloskey, E.V., Rosini, S., Coleman, R.E., Kanis, J.A. Br. J. Cancer (1994) [Pubmed]
Beneficial effects of aminohexane diphosphonate in patients with Paget's disease of bone resistant to sodium etidronate. Delmas, P.D., Chapuy, M.C., Edouard, C., Meunier, P.J. Am. J. Med. (1987) [Pubmed]

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