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Chemical Compound Review

diphosphonate     oxido-(oxido-oxo- phosphaniumyl)oxy-oxo...

Synonyms: CHEBI:29262, IN2857, AKOS015903585, P1746, I14-18086, ...
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Disease relevance of diphosphonate


High impact information on diphosphonate


Chemical compound and disease context of diphosphonate


Biological context of diphosphonate


Anatomical context of diphosphonate


Associations of diphosphonate with other chemical compounds


Gene context of diphosphonate


Analytical, diagnostic and therapeutic context of diphosphonate


  1. Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis. Storm, T., Thamsborg, G., Steiniche, T., Genant, H.K., Sørensen, O.H. N. Engl. J. Med. (1990) [Pubmed]
  2. Use of dichloromethylene diphosphonate in metastatic bone disease. Jung, A., Chantraine, A., Donath, A., van Ouwenaller, C., Turnill, D., Mermillod, B., Kitler, M.E. N. Engl. J. Med. (1983) [Pubmed]
  3. Effects of dichloromethylene diphosphonate on skeletal mobilization of calcium in multiple myeloma. Siris, E.S., Sherman, W.H., Baquiran, D.C., Schlatterer, J.P., Osserman, E.F., Canfield, R.E. N. Engl. J. Med. (1980) [Pubmed]
  4. Bone metastases and bone pain in breast cancer. Are they closely associated? Front, D., Schneck, S.O., Frankel, A., Robinson, E. JAMA (1979) [Pubmed]
  5. Long-term controlled trial with diphosphonate in patients with osteolytic bone metastases. Elomaa, I., Blomqvist, C., Gröhn, P., Porkka, L., Kairento, A.L., Selander, K., Lamberg-Allardt, C., Holmström, T. Lancet (1983) [Pubmed]
  6. Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate. Levy, R.J., Wolfrum, J., Schoen, F.J., Hawley, M.A., Lund, S.A., Langer, R. Science (1985) [Pubmed]
  7. The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung. Limper, A.H., Hoyte, J.S., Standing, J.E. J. Clin. Invest. (1997) [Pubmed]
  8. Focal osteomalacia due to low-dose diphosphonate therapy in Paget's disease. Boyce, B.F., Smith, L., Fogelman, I., Johnston, E., Ralston, S., Boyle, I.T. Lancet (1984) [Pubmed]
  9. Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease. Douglas, D.L., Duckworth, T., Russell, R.G., Kanis, J.A., Preston, C.J., Preston, F.E., Prenton, M.A., Woodhead, J.S. Lancet (1980) [Pubmed]
  10. Renal excretion of technetium-99m diphosphonate in osteomalacia. Fogelman, I., Bessent, R.G. Ann. Intern. Med. (1979) [Pubmed]
  11. Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia. Doppelt, S.H., Slovik, D.M., Neer, R.M., Nolan, J., Zusman, R.M., Potts, J.T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  12. Inhibition by diphosphonates of bone resorption induced by the Walker tumor of the rat. Jung, A., Bornand, J., Mermillod, B., Edouard, C., Meunier, P.J. Cancer Res. (1984) [Pubmed]
  13. Long-term therapy of Paget's disease of bone with EHDP. Siris, E.S., Canfield, R.E., Jacobs, T.P., Baquiran, D.C. Arthritis Rheum. (1980) [Pubmed]
  14. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. Leemans, J.C., Juffermans, N.P., Florquin, S., van Rooijen, N., Vervoordeldonk, M.J., Verbon, A., van Deventer, S.J., van der Poll, T. J. Immunol. (2001) [Pubmed]
  15. Studies of 5'-nucleotidase in the perfused rat heart. Including measurements of the enzyme in perfused skeletal muscle and liver. Frick, G.P., Lowenstein, J.M. J. Biol. Chem. (1976) [Pubmed]
  16. Heterotopic bone formation (myositis ossificans) and lower-extremity swelling mimicking deep-venous disease. Orzel, J.A., Rudd, T.G., Nelp, W.B. J. Nucl. Med. (1984) [Pubmed]
  17. Imaging of malignant bone involvement by morphologic, scintigraphic, and hybrid modalities. Even-Sapir, E. J. Nucl. Med. (2005) [Pubmed]
  18. Endocrine and pharmacological suppressors of bone turnover protect against osteopenia in ovariectomized rats. Wronski, T.J., Dann, L.M., Scott, K.S., Crooke, L.R. Endocrinology (1989) [Pubmed]
  19. Immediate renal imaging and renography with 99mTc methylene diphosphonate to assess renal blood flow, excretory function, and anatomy. Glass, E.C., DeNardo, G.L., Hines, H.H. Radiology. (1980) [Pubmed]
  20. Effects of dichloromethylene diphosphonate on serum and urinary calcium in primary hyperparathyroidism. Shane, E., Baquiran, D.C., Bilezikian, J.P. Ann. Intern. Med. (1981) [Pubmed]
  21. An experimental rat model of local bone cancer invasion and its responsiveness to ethane-1-hydroxy-1,1-bis(phosphonate). Guaitani, A., Sabatini, M., Coccioli, G., Cristina, S., Garattini, S., Bartosek, I. Cancer Res. (1985) [Pubmed]
  22. Tumor necrosis factor-induced, superoxide-mediated neutrophil accumulation in cold ischemic/reperfused rat liver. Shibuya, H., Ohkohchi, N., Tsukamoto, S., Satomi, S. Hepatology (1997) [Pubmed]
  23. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. van Lent, P.L., Holthuysen, A.E., van den Bersselaar, L.A., van Rooijen, N., Joosten, L.A., van de Loo, F.A., van de Putte, L.B., van den Berg, W.B. Arthritis Rheum. (1996) [Pubmed]
  24. Prospective evaluation of sacroiliac scintigraphy in chronic inflammatory back pain. Esdaile, J.M., Rosenthall, L., Terkeltaub, R., Kloiber, R. Arthritis Rheum. (1980) [Pubmed]
  25. Technetium-99m diphosphonate retention in hyperparathyroidism. Heath, H. Ann. Intern. Med. (1980) [Pubmed]
  26. Kupffer cell depletion partially prevents hepatic heme oxygenase 1 messenger RNA accumulation in systemic inflammation in mice: role of interleukin 1beta. Rizzardini, M., Zappone, M., Villa, P., Gnocchi, P., Sironi, M., Diomede, L., Meazza, C., Monshouwer, M., Cantoni, L. Hepatology (1998) [Pubmed]
  27. Effects of diphosphonates on glycosaminoglycan synthesis and proteoglycan aggregation in normal adult articular cartilage. Palmoski, M., Brandt, K. Arthritis Rheum. (1978) [Pubmed]
  28. Secondary hyperparathyroidism associated with dichloromethane diphosphonate treatment of Paget's disease. Harris, S.T., Neer, R.M., Segre, G.V., Petkau, A.J., Tully, G.L., Daly, M., Potts, J.T. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  29. Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity. Thepen, T., McMenamin, C., Oliver, J., Kraal, G., Holt, P.G. Eur. J. Immunol. (1991) [Pubmed]
  30. Fever after zoledronic acid administration is due to increase in TNF-alpha and IL-6. Dicuonzo, G., Vincenzi, B., Santini, D., Avvisati, G., Rocci, L., Battistoni, F., Gavasci, M., Borzomati, D., Coppola, R., Tonini, G. J. Interferon Cytokine Res. (2003) [Pubmed]
  31. Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis. Okazaki, K., Nakase, H., Watanabe, N., Tabata, Y., Ikada, Y., Chiba, T. J. Gastroenterol. (2002) [Pubmed]
  32. Action of tumoral PTH-related peptide on phosphate and calcium transport. Bonjour, J.P., Rizzoli, R., Pizurki, L., Caverzasio, J. Prog. Clin. Biol. Res. (1990) [Pubmed]
  33. Whole body retention of diphosphonate in rheumatoid arthritis. Steven, M.M., Sturrock, R.D., Fogelman, I., Smith, M.L. J. Rheumatol. (1982) [Pubmed]
  34. Diphosphonates and phosphate homoeostasis in man. McCloskey, E.V., Yates, A.J., Gray, R.E., Hamdy, N.A., Galloway, J., Kanis, J.A. Clin. Sci. (1988) [Pubmed]
  35. Symptomatic hypocalcaemia after treatment with high-dose aminohydroxypropylidene diphosphonate. Jodrell, D.I., Iveson, T.J., Smith, I.E. Lancet (1987) [Pubmed]
  36. Circulation of human hematopoietic cells in severe combined immunodeficient mice after Cl2MDP-liposome-mediated macrophage depletion. Fraser, C.C., Chen, B.P., Webb, S., van Rooijen, N., Kraal, G. Blood (1995) [Pubmed]
  37. Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to the skeleton. Siris, E.S., Hyman, G.A., Canfield, R.E. Am. J. Med. (1983) [Pubmed]
  38. Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo. Kuzmin, A.I., Finegold, M.J., Eisensmith, R.C. Gene Ther. (1997) [Pubmed]
  39. Maximum-likelihood reconstruction with ordered subsets in bone SPECT. Blocklet, D., Seret, A., Popa, N., Schoutens, A. J. Nucl. Med. (1999) [Pubmed]
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