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Chemical Compound Review:

Eptapirone 4-methyl-2-[4-(4-pyrimidin-2- ylpiperazin-1...

Synonyms: SureCN678195, CHEMBL2104230, AC1L4LMM, CTK8H3201, AR-1G3317, ...

Koek, W. et al., Wilson, S.J. et al., Wilson, S.J. et al.

Wilson, Bailey, Rich, Nash, Adrover, Tournoux, Nutt,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Eptapirone

Dizziness produced by a potent 5HT(1A) receptor agonist (eptapirone) is not due to postural hypotension [1].

Psychiatry related information on Eptapirone

Wakefulness in sleep was significantly greatest after morning eptapirone [2].

High impact information on Eptapirone

F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential [3].
Consistent with the aforementioned hypothesis, F 11440 produced anxiolytic- and antidepressant-like effects in animal models (i.e., increased punished responding in a pigeon conflict procedure and decreased immobility in a rat forced swimming test, respectively) that were more substantial than those of buspirone, ipsapirone and flesinoxan [3].
The objective of this study was to examine the effects of eptapirone on sleep architecture, particularly REM sleep, in normal volunteers and compare it with buspirone and placebo [2].

References

Dizziness produced by a potent 5HT(1A) receptor agonist (eptapirone) is not due to postural hypotension. Wilson, S.J., Bailey, J.E., Nutt, D.J. Psychopharmacology (Berl.) (2005) [Pubmed]
The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Wilson, S.J., Bailey, J.E., Rich, A.S., Nash, J., Adrover, M., Tournoux, A., Nutt, D.J. J. Psychopharmacol. (Oxford) (2005) [Pubmed]
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. Koek, W., Patoiseau, J.F., Assié, M.B., Cosi, C., Kleven, M.S., Dupont-Passelaigue, E., Carilla-Durand, E., Palmier, C., Valentin, J.P., John, G., Pauwels, P.J., Tarayre, J.P., Colpaert, F.C. J. Pharmacol. Exp. Ther. (1998) [Pubmed]

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