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Chemical Compound Review

Eptapirone     4-methyl-2-[4-(4-pyrimidin-2- ylpiperazin-1...

Synonyms: SureCN678195, CHEMBL2104230, AC1L4LMM, CTK8H3201, AR-1G3317, ...
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Disease relevance of Eptapirone


Psychiatry related information on Eptapirone


High impact information on Eptapirone

  • F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential [3].
  • Consistent with the aforementioned hypothesis, F 11440 produced anxiolytic- and antidepressant-like effects in animal models (i.e., increased punished responding in a pigeon conflict procedure and decreased immobility in a rat forced swimming test, respectively) that were more substantial than those of buspirone, ipsapirone and flesinoxan [3].
  • The objective of this study was to examine the effects of eptapirone on sleep architecture, particularly REM sleep, in normal volunteers and compare it with buspirone and placebo [2].


  1. Dizziness produced by a potent 5HT(1A) receptor agonist (eptapirone) is not due to postural hypotension. Wilson, S.J., Bailey, J.E., Nutt, D.J. Psychopharmacology (Berl.) (2005) [Pubmed]
  2. The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. Wilson, S.J., Bailey, J.E., Rich, A.S., Nash, J., Adrover, M., Tournoux, A., Nutt, D.J. J. Psychopharmacol. (Oxford) (2005) [Pubmed]
  3. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. Koek, W., Patoiseau, J.F., Assié, M.B., Cosi, C., Kleven, M.S., Dupont-Passelaigue, E., Carilla-Durand, E., Palmier, C., Valentin, J.P., John, G., Pauwels, P.J., Tarayre, J.P., Colpaert, F.C. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
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