Chemical Compound Review:
Flesinoxan 4-fluoro-N-[2-[4-[(8S)-8- (hydroxymethyl)-7...
Synonyms:
SureCN220401, CHEMBL1742477, LS-26502, PDSP1_000766, PDSP2_000754, ...
Miczek,
Hussain,
Faccidomo,
Janssen,
Prins,
Moreaux,
Meulemans,
Lefebvre,
Bouwknecht,
van der Gugten,
Hijzen,
Maes,
Hen,
Olivier,
Sibug,
Compaan,
Meijer,
Van der Gugten,
Olivier,
De Kloet,
Monti,
Jantos,
Monti,
Jantos,
Pitchot,
Wauthy,
Legros,
Ansseau,
Pitchot,
Wauthy,
Hansenne,
Pinto,
Fuchs,
Reggers,
Legros,
Ansseau,
Bosker,
Cremers,
Jongsma,
Westerink,
Wikström,
den Boer,
Olivier,
Molewijk,
van der Heyden,
van Oorschot,
Ronken,
Mos,
Miczek,
Kuipers,
Kruse,
van Wijngaarden,
Standaar,
Tulp,
Veldman,
Spek,
IJzerman,
Pattij,
Groenink,
Hijzen,
Oosting,
Maes,
van der Gugten,
Olivier,
Bantick,
Rabiner,
Hirani,
de Vries,
Hume,
Grasby,
- Ultrasonic vocalizations in rat pups: effects of serotonergic ligands. Olivier, B., Molewijk, H.E., van der Heyden, J.A., van Oorschot, R., Ronken, E., Mos, J., Miczek, K.A. Neuroscience and biobehavioral reviews. (1998)
- Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout mice. Pattij, T., Groenink, L., Hijzen, T.H., Oosting, R.S., Maes, R.A., van der Gugten, J., Olivier, B. Neuropsychopharmacology (2002)
- The cardiovascular and renal functional responses to the 5-HT1A receptor agonist flesinoxan in two rat models of hypertension. Chamienia, A.L., Johns, E.J. Br. J. Pharmacol. (1996)
- Agonist occupation of serotonin1A receptors in the rat hippocampus prevents their inactivation by pertussis toxin. Hadrava, V., Blier, P., de Montigny, C. Neuroscience (1994)
- Behavioral and physiological mouse models for anxiety: effects of flesinoxan in 129S6/SvEvTac and C57BL/6J mice. Adriaan Bouwknecht, J., van der Gugten, J., Groenink, L., Olivier, B., Paylor, R.E. Eur. J. Pharmacol. (2004)
- The effect of 5-HT1A receptor agonists on locomotor activity in the guinea-pig. Evenden, J.L. Br. J. Pharmacol. (1994)
- Effects of the 5-HT1A receptor agonist flesinoxan in panic disorder. van Vliet, I.M., Westenberg, H.G., den Boer, J.A. Psychopharmacology (Berl.) (1996)
- Different effects of 5-HT1A receptor agonists and benzodiazepine anxiolytics on the emotional state of naive and stressed mice: a study using the hole-board test. Tsuji, M., Takeda, H., Matsumiya, T. Psychopharmacology (Berl.) (2000)
- Increased REM sleep after intra-dorsal raphe nucleus injection of flesinoxan or 8-OHDPAT: prevention with WAY 100635. Monti, J.M., Jantos, H., Monti, D. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2002)
- Differential effects of the 5-HT1A receptor agonist flesinoxan given locally or systemically on REM sleep in the rat. Monti, J.M., Jantos, H. Eur. J. Pharmacol. (2003)
- Occupancy of agonist drugs at the 5-HT1A receptor. Bantick, R.A., Rabiner, E.A., Hirani, E., de Vries, M.H., Hume, S.P., Grasby, P.M. Neuropsychopharmacology (2004)
- Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala. Bosker, F.J., Cremers, T.I., Jongsma, M.E., Westerink, B.H., Wikström, H.V., den Boer, J.A. J. Neurochem. (2001)
- 5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines. Kuipers, W., Kruse, C.G., van Wijngaarden, I., Standaar, P.J., Tulp, M.T., Veldman, N., Spek, A.L., IJzerman, A.P. J. Med. Chem. (1997)
- Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors. Bosker, F.J., de Winter, T.Y., Klompmakers, A.A., Westenberg, H.G. J. Neurochem. (1996)
- Serotonin1A receptor activation by flesinoxan in humans. Body temperature and neuroendocrine responses. Seletti, B., Benkelfat, C., Blier, P., Annable, L., Gilbert, F., de Montigny, C. Neuropsychopharmacology (1995)
- Effects of the 5-HT1A receptor ligands flesinoxan and WAY 100635 given systemically or microinjected into the laterodorsal tegmental nucleus on REM sleep in the rat. Monti, J.M., Jantos, H. Behav. Brain Res. (2004)
- Comparison of the cardiovascular effects of the 5-HT1A receptor agonist flesinoxan with that of 8-OH-DPAT in the rat. Dreteler, G.H., Wouters, W., Saxena, P.R. Eur. J. Pharmacol. (1990)
- Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. Lucot, J.B. Eur. J. Pharmacol. (1994)
- Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. McCall, R.B., Escandon, N.A., Harris, L.T., Clement, M.E. J. Pharmacol. Exp. Ther. (1994)
- Renal functional responses to the 5-HT1A receptor agonist flesinoxan: effects of controlled renal perfusion pressure. Chamienia, A.L., Johns, E.J. J. Pharmacol. Exp. Ther. (1994)
- Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Hadrava, V., Blier, P., Dennis, T., Ortemann, C., de Montigny, C. Neuropharmacology (1995)
- Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels. Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. Eur. J. Pharmacol. (1998)
- Cardiovascular effects following injection of 8-OH-DPAT and flesinoxan into the dorsal raphe nucleus of conscious rats. Connor, H.E., Higgins, G.A. Br. J. Pharmacol. (1989)
- 5-HT1A receptor agonist flesinoxan enhances Fos immunoreactivity in rat central amygdala, bed nucleus of the stria terminalis and hypothalamus. Compaan, J.C., Groenink, L., van der Gugten, J., Maes, R.A., Olivier, B. Eur. J. Neurosci. (1996)
- Microinjections of 5-HT1A agonists into the dorsal motor vagal nucleus produce a bradycardia in the atenolol-pretreated anaesthetized rat. Sporton, S.C., Shepheard, S.L., Jordan, D., Ramage, A.G. Br. J. Pharmacol. (1991)
- Enhancement and depression of spinal reflexes by 8-hydroxy-2-(di-n-propylamino)tetralin in the decerebrated and spinalized rabbit: involvement of 5-HT1A- and non-5-HT1A-receptors. Clarke, R.W., Ogilvie, J., Houghton, A.K. Br. J. Pharmacol. (1997)
- Flesinoxan pretreatment differentially affects corticosterone, prolactin and behavioural responses to a flesinoxan challenge. Groenink, L., Van der Gugten, J., Compaan, J.C., Maes, R.A., Olivier, B. Psychopharmacology (Berl.) (1997)
- Hormonal and temperature responses to the 5-HT1A receptor agonist flesinoxan in normal volunteers. Pitchot, W., Wauthy, J., Hansenne, M., Pinto, E., Fuchs, S., Reggers, J., Legros, J.J., Ansseau, M. Psychopharmacology (Berl.) (2002)
- In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs. Janssen, P., Prins, N.H., Moreaux, B., Meulemans, A.L., Lefebvre, R.A. Br. J. Pharmacol. (2003)
- Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs. Molewijk, H.E., Hartog, K., van der Poel, A.M., Mos, J., Olivier, B. Psychopharmacology (Berl.) (1996)
- Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal. Bouwknecht, J.A., van der Gugten, J., Hijzen, T.H., Maes, R.A., Hen, R., Olivier, B. Psychopharmacology (Berl.) (2001)
- Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study. Pitchot, W., Wauthy, J., Legros, J.J., Ansseau, M. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2004)
- A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers. de Koning, P., de Vries, M.H. British journal of clinical pharmacology. (1995)
- Effects of flesinoxan on corticosteroid receptor expression in the rat hippocampus. Sibug, R.M., Compaan, J.C., Meijer, O.C., Van der Gugten, J., Olivier, B., De Kloet, E.R. Eur. J. Pharmacol. (2000)
- Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. van der Sandt, I.C., Smolders, R., Nabulsi, L., Zuideveld, K.P., de Boer, A.G., Breimer, D.D. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2001)
- Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Miczek, K.A., Hussain, S., Faccidomo, S. Psychopharmacology (Berl.) (1998)
- Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat. Dreteler, G.H., Wouters, W., Saxena, P.R., Ramage, A.G. Br. J. Pharmacol. (1991)