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Chemical Compound Review:

Activin [(8R,9S,10R,13S,14S,17S)-13- methyl-3-oxo-2...

Synonyms: Anabosan, Durabol, Durabolin, Duranox, Equibolin, ...

Jones, K.L. et al., Shafiee-Kermani, F. et al., Wu, Z. et al., Antenos, M. et al., Mukerji, S.S. et al.

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Disease relevance of Activin

Activin was also increased after 2 h of 11% hypoxia [1].

Associations of Activin with other chemical compounds

These data support the concept that chronic GnRH inhibits activin-induced ovine FSHB expression by sequential activation of CREB and NOSI through the cAMP and/or protein kinase C pathways [2].

Gene context of Activin

Further, mice administered one 10-mug dose of follistatin to block activin effects have increased survival after a lethal dose of LPS, and the circulating levels of activin correlate with survival outcome [3].
We also show that the trophoblast induction effect of BMP4 correlates with and depends on the inhibition of Activin/Nodal signaling [4].
Simultaneously, activin stimulated the proconvertase furin through a Smad2/3-dependent process [5].

References

Activin is a neuronal survival factor that is rapidly increased after transient cerebral ischemia and hypoxia in mice. Mukerji, S.S., Katsman, E.A., Wilber, C., Haner, N.A., Selman, W.R., Hall, A.K. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
Chronic gonadotropin-releasing hormone inhibits activin induction of the ovine follicle-stimulating hormone beta-subunit: involvement of 3',5'-cyclic adenosine monophosphate response element binding protein and nitric oxide synthase type I. Shafiee-Kermani, F., Han, S.O., Miller, W.L. Endocrinology (2007) [Pubmed]
Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Jones, K.L., Mansell, A., Patella, S., Scott, B.J., Hedger, M.P., de Kretser, D.M., Phillips, D.J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. Wu, Z., Zhang, W., Chen, G., Cheng, L., Liao, J., Jia, N., Gao, Y., Dai, H., Yuan, J., Cheng, L., Xiao, L. J. Biol. Chem. (2008) [Pubmed]
An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells. Antenos, M., Zhu, J., Jetly, N.M., Woodruff, T.K. J. Biol. Chem. (2008) [Pubmed]

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