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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Trophoblasts


Psychiatry related information on Trophoblasts


High impact information on Trophoblasts

  • We show here that this event can be mimicked by overexpression of Caudal-related homeobox 2 (Cdx2), which is sufficient to generate proper trophoblast stem (TS) cells [8].
  • Four STOX1 transcripts are expressed in early placenta, including invasive extravillus trophoblast, generating three different isoforms [1].
  • In addition, chorionic trophoblast cells in Gcm1-deficient placentas do not fuse to form syncytiotrophoblast [9].
  • The chorioallantoic villi develop after embryonic day (E) 8.5 through extensive folding and branching of an initially flat sheet of trophoblast cells, the chorionic plate, in response to contact with the allantois [9].
  • After implantation, Hand1 expression is restricted to placental trophoblast cells and later to embryonic cardiac and neural crest cells [10].

Chemical compound and disease context of Trophoblasts


Biological context of Trophoblasts


Anatomical context of Trophoblasts


Associations of Trophoblasts with chemical compounds


Gene context of Trophoblasts


Analytical, diagnostic and therapeutic context of Trophoblasts


  1. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. van Dijk, M., Mulders, J., Poutsma, A., Könst, A.A., Lachmeijer, A.M., Dekker, G.A., Blankenstein, M.A., Oudejans, C.B. Nat. Genet. (2005) [Pubmed]
  2. Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death. Chamley, L.W., Duncalf, A.M., Mitchell, M.D., Johnson, P.M. Lancet (1998) [Pubmed]
  3. Cytological distribution of chorionic gonadotropin subunit and placental lactogen messenger RNA in neoplasms derived from human placenta. Hoshina, M., Hussa, R., Pattillo, R., Boime, I. J. Cell Biol. (1983) [Pubmed]
  4. Keratin 8 protection of placental barrier function. Jaquemar, D., Kupriyanov, S., Wankell, M., Avis, J., Benirschke, K., Baribault, H., Oshima, R.G. J. Cell Biol. (2003) [Pubmed]
  5. The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Mallet, F., Bouton, O., Prudhomme, S., Cheynet, V., Oriol, G., Bonnaud, B., Lucotte, G., Duret, L., Mandrand, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Maternal regulation of embryonic growth: the role of vasoactive intestinal peptide. Spong, C.Y., Lee, S.J., McCune, S.K., Gibney, G., Abebe, D.T., Alvero, R., Brenneman, D.E., Hill, J.M. Endocrinology (1999) [Pubmed]
  7. A search for antibodies in term maternal sera to solubilized syncytiotrophoblast surface components. A passive haemagglutination assay yields negative evidence. Nickson, D.A., Sutcliffe, R.G. J. Reprod. Immunol. (1986) [Pubmed]
  8. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., Rossant, J. Cell (2005) [Pubmed]
  9. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Anson-Cartwright, L., Dawson, K., Holmyard, D., Fisher, S.J., Lazzarini, R.A., Cross, J.C. Nat. Genet. (2000) [Pubmed]
  10. The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Riley, P., Anson-Cartwright, L., Cross, J.C. Nat. Genet. (1998) [Pubmed]
  11. Sustained hyperglycemia in vitro down-regulates the GLUT1 glucose transport system of cultured human term placental trophoblast: a mechanism to protect fetal development? Hahn, T., Barth, S., Weiss, U., Mosgoeller, W., Desoye, G. FASEB J. (1998) [Pubmed]
  12. Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Lim, K.H., Zhou, Y., Janatpour, M., McMaster, M., Bass, K., Chun, S.H., Fisher, S.J. Am. J. Pathol. (1997) [Pubmed]
  13. Bromo-adenosine stimulates choriogonadotropin production in JAr and cytotrophoblast cells: evidence for effects on two stages of differentiation. Sibley, C.P., Hochberg, A., Boime, I. Mol. Endocrinol. (1991) [Pubmed]
  14. The expression and activity of prostaglandin H synthase-2 is enhanced in trophoblast from women with preeclampsia. Johnson, R.D., Sadovsky, Y., Graham, C., Anteby, E.Y., Polakoski, K.L., Huang, X., Nelson, D.M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  15. Trophoblast and placental villous core production of lipid peroxides, thromboxane, and prostacyclin in preeclampsia. Walsh, S.W., Wang, Y. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  16. Plasminogen activator in early embryogenesis: enzyme production by trophoblast and parietal endoderm. Strickland, S., Reich, E., Sherman, M.I. Cell (1976) [Pubmed]
  17. Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth. Li, Y., Behringer, R.R. Nat. Genet. (1998) [Pubmed]
  18. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: compaction and trophoblast adhesion. Surani, M.A. Cell (1979) [Pubmed]
  19. Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Guillemot, F., Caspary, T., Tilghman, S.M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Anderson, D.J., Joyner, A.L., Rossant, J., Nagy, A. Nat. Genet. (1995) [Pubmed]
  20. Gap junctional communication in the preimplantation mouse embryo. Lo, C.W., Gilula, N.B. Cell (1979) [Pubmed]
  21. Pregnancy loss in the antiphospholipid-antibody syndrome--a possible thrombogenic mechanism. Rand, J.H., Wu, X.X., Andree, H.A., Lockwood, C.J., Guller, S., Scher, J., Harpel, P.C. N. Engl. J. Med. (1997) [Pubmed]
  22. Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Imakawa, K., Anthony, R.V., Kazemi, M., Marotti, K.R., Polites, H.G., Roberts, R.M. Nature (1987) [Pubmed]
  23. Eomesodermin is required for mouse trophoblast development and mesoderm formation. Russ, A.P., Wattler, S., Colledge, W.H., Aparicio, S.A., Carlton, M.B., Pearce, J.J., Barton, S.C., Surani, M.A., Ryan, K., Nehls, M.C., Wilson, V., Evans, M.J. Nature (2000) [Pubmed]
  24. Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Pepe, G.J., Albrecht, E.D. Endocr. Rev. (1995) [Pubmed]
  25. Prevention of allogeneic fetal rejection by tryptophan catabolism. Munn, D.H., Zhou, M., Attwood, J.T., Bondarev, I., Conway, S.J., Marshall, B., Brown, C., Mellor, A.L. Science (1998) [Pubmed]
  26. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Wu, J., Motto, D.G., Koretzky, G.A., Weiss, A. Immunity (1996) [Pubmed]
  27. Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. Drake, P.M., Gunn, M.D., Charo, I.F., Tsou, C.L., Zhou, Y., Huang, L., Fisher, S.J. J. Exp. Med. (2001) [Pubmed]
  28. Increased sialylation of surface glycopeptides of human trophoblast compared with fetal cells from the same conceptus. Whyte, A., Loke, Y.W. J. Exp. Med. (1978) [Pubmed]
  29. A class I antigen, HLA-G, expressed in human trophoblasts. Kovats, S., Main, E.K., Librach, C., Stubblebine, M., Fisher, S.J., DeMars, R. Science (1990) [Pubmed]
  30. Defective trophoblast function in mice with a targeted mutation of Ets2. Yamamoto, H., Flannery, M.L., Kupriyanov, S., Pearce, J., McKercher, S.R., Henkel, G.W., Maki, R.A., Werb, Z., Oshima, R.G. Genes Dev. (1998) [Pubmed]
  31. Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Adelman, D.M., Gertsenstein, M., Nagy, A., Simon, M.C., Maltepe, E. Genes Dev. (2000) [Pubmed]
  32. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Firulli, B.A., Howard, M.J., McDaid, J.R., McIlreavey, L., Dionne, K.M., Centonze, V.E., Cserjesi, P., Virshup, D.M., Firulli, A.B. Mol. Cell (2003) [Pubmed]
  33. A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. Rajagopalan, S., Long, E.O. J. Exp. Med. (1999) [Pubmed]
  34. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. Roth, I., Corry, D.B., Locksley, R.M., Abrams, J.S., Litton, M.J., Fisher, S.J. J. Exp. Med. (1996) [Pubmed]
  35. Decidua produces a protein that inhibits choriogonadotrophin release from human trophoblasts. Ren, S.G., Braunstein, G.D. J. Clin. Invest. (1991) [Pubmed]
  36. Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. Hajenius, P.J., Engelsbel, S., Mol, B.W., Van der Veen, F., Ankum, W.M., Bossuyt, P.M., Hemrika, D.J., Lammes, F.B. Lancet (1997) [Pubmed]
  37. Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium. Stuart, S.G., Simister, N.E., Clarkson, S.B., Kacinski, B.M., Shapiro, M., Mellman, I. EMBO J. (1989) [Pubmed]
  38. Expression and function of cell surface extracellular matrix receptors in mouse blastocyst attachment and outgrowth. Sutherland, A.E., Calarco, P.G., Damsky, C.H. J. Cell Biol. (1988) [Pubmed]
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