The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

DEMETON     1-(2- diethoxyphosphorylsulfanylethy lsulfan...

Synonyms: ISOSYSTOX, Izosystox, Isodemeton, Demetonthiol, Thioldemeton, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ISOSYSTOX


Associations of ISOSYSTOX with other chemical compounds

  • As a preliminary step to such screening we have measured the hydrolysis of O,O-diisopropyl S-(2-diisopropylaminoethyl) phosphorothiolate (Tetriso) and O,O-diethyl S-(2-ethylthioethyl) phosphorothiolate (Demeton-S; formerly Isosystox) by intact cells and sonicates [4].

Analytical, diagnostic and therapeutic context of ISOSYSTOX

  • The applicability of the biosensor was demonstrated for direct, rapid, and selective detection of V-type nerve agents' mimic demeton-S [5].


  1. Modification of near active site residues in organophosphorus hydrolase reduces metal stoichiometry and alters substrate specificity. diSioudi, B., Grimsley, J.K., Lai, K., Wild, J.R. Biochemistry (1999) [Pubmed]
  2. Lipsome-formulated enzymes for organophosphate scavenging: butyrylcholinesterase and Demeton-S. Fischer, S., Arad, A., Margalit, R. Arch. Biochem. Biophys. (2005) [Pubmed]
  3. Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase. Lai, K., Stolowich, N.J., Wild, J.R. Arch. Biochem. Biophys. (1995) [Pubmed]
  4. Degradation of nerve gases by CLECS and cells: kinetics of heterogenous systems. Hoskin, F.C., Walker, J.E., Stote, R. Chem. Biol. Interact. (1999) [Pubmed]
  5. V-type nerve agent detection using a carbon nanotube-based amperometric enzyme electrode. Joshi, K.A., Prouza, M., Kum, M., Wang, J., Tang, J., Haddon, R., Chen, W., Mulchandani, A. Anal. Chem. (2006) [Pubmed]
WikiGenes - Universities