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Chemical Compound Review:

DEMETON 1-(2- diethoxyphosphorylsulfanylethy lsulfan...

Synonyms: ISOSYSTOX, Izosystox, Isodemeton, Demetonthiol, Thioldemeton, ...

diSioudi, B. et al., Hoskin, F.C. et al., Lai, K. et al., Joshi, K.A. et al., Fischer, S. et al.

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High impact information on ISOSYSTOX

The three altered enzymes achieved a 2-30-fold increase in substrate specificity (kcat/Km) for demeton S (P-S bond), an analogue for the chemical warfare agent VX [1].
Lipsome-formulated enzymes for organophosphate scavenging: butyrylcholinesterase and Demeton-S [2].
Phosphorothiolate esters, such as demeton-S, provided noncompetitive inhibition for paraoxon (a P-O triester) hydrolysis, suggesting that the binding of these two different classes of substrates was not identical [3].

Associations of ISOSYSTOX with other chemical compounds

As a preliminary step to such screening we have measured the hydrolysis of O,O-diisopropyl S-(2-diisopropylaminoethyl) phosphorothiolate (Tetriso) and O,O-diethyl S-(2-ethylthioethyl) phosphorothiolate (Demeton-S; formerly Isosystox) by intact cells and sonicates [4].

Analytical, diagnostic and therapeutic context of ISOSYSTOX

The applicability of the biosensor was demonstrated for direct, rapid, and selective detection of V-type nerve agents' mimic demeton-S [5].

References

Modification of near active site residues in organophosphorus hydrolase reduces metal stoichiometry and alters substrate specificity. diSioudi, B., Grimsley, J.K., Lai, K., Wild, J.R. Biochemistry (1999) [Pubmed]
Lipsome-formulated enzymes for organophosphate scavenging: butyrylcholinesterase and Demeton-S. Fischer, S., Arad, A., Margalit, R. Arch. Biochem. Biophys. (2005) [Pubmed]
Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase. Lai, K., Stolowich, N.J., Wild, J.R. Arch. Biochem. Biophys. (1995) [Pubmed]
Degradation of nerve gases by CLECS and cells: kinetics of heterogenous systems. Hoskin, F.C., Walker, J.E., Stote, R. Chem. Biol. Interact. (1999) [Pubmed]
V-type nerve agent detection using a carbon nanotube-based amperometric enzyme electrode. Joshi, K.A., Prouza, M., Kum, M., Wang, J., Tang, J., Haddon, R., Chen, W., Mulchandani, A. Anal. Chem. (2006) [Pubmed]

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