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Gene Review

Bche  -  butyrylcholinesterase

Rattus norvegicus

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Disease relevance of Bche


Psychiatry related information on Bche

  • In rats pretreated intravenously with 5,000 IU of horse serum-derived BChE, the locomotor activity effect was significantly attenuated [5].

High impact information on Bche


Chemical compound and disease context of Bche


Biological context of Bche


Anatomical context of Bche

  • These data support a role of the glia marker BChE in CNS glial cell proliferation and differentiation, achieved via a nonenzymatic mechanism [11].
  • This finding indicates that the regulation of BuChE may be strongly affected by hormones under the control of the pituitary gland [12].
  • Peak inhibition of maternal spinal cord AChE and BuChE activities occurred 2 h and 1 h after dosing, respectively [13].
  • Acetylcholinesterase activity in erythrocytes as well as butyrylcholinesterase activity in plasma were significantly decreased in both groups of animals after intoxication with sarin [14].
  • The concentration of exogenous ACh needed to reduce the spontaneous frequency of contractions of the isolated right atrium by 30, 60, or 90/min fell by 78%, 79% and 84% respectively after BW 284 C51 inhibition of AChE and by 95%, 94% and 94% after simultaneous inhibition of AChE and BuChE [15].

Associations of Bche with chemical compounds


Other interactions of Bche


Analytical, diagnostic and therapeutic context of Bche

  • Most of the effects of hypophysectomy on mean BuChE activity were opposite in direction in the two sexes [12].
  • The individual molecular forms (10S and 4S) of maternal and fetal brain AChE and BuChE activities were significantly decreased 1 h after treatment [13].
  • Denervation of muscle caused a dramatic reduction in the presence of AchE molecular forms with no discernable influence on the presence of BuchE molecular forms [23].
  • At 1 1/2 hr after the treatments, the BuChE activity was too low to be detected on the gels, but 24 hr thereafter, the quantitative determination of the different forms, performed by scanning densitometry, showed a significant increase of the two faster migrating ones [24].
  • Heparin-Sepharose chromatography, nondenaturing electrophoresis and sucrose gradient centrifugation were used to study heparin interaction with the G2 form BChE [25].


  1. Identification of the probable site of synthesis of butyrylcholinesterase in the superior cervical and ciliary ganglia of the cat. Uchida, E., Koelle, G.B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  2. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Yang, Z.P., Dettbarn, W.D. Biochem. Pharmacol. (1998) [Pubmed]
  3. Reduction of butyrylcholinesterase activity in rat serum subjected to hyperhomocysteinemia. Stefanello, F.M., Franzon, R., Tagliari, B., Wannmacher, C., Wajner, M., Wyse, A.T. Metabolic brain disease. (2005) [Pubmed]
  4. Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. Ramkumar, K.M., Latha, M., Ashokkumar, N., Pari, L., Ananthan, R. Journal of basic and clinical physiology and pharmacology. (2005) [Pubmed]
  5. Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase. Carmona, G.N., Schindler, C.W., Shoaib, M., Jufer, R., Cone, E.J., Goldberg, S.R., Greig, N.H., Yu, Q.S., Gorelick, D.A. Experimental and clinical psychopharmacology. (1998) [Pubmed]
  6. Histochemical and cytochemical study of butyrylcholinesterase activity in rat hepatocellular carcinomas induced by 3'-methyl-4-dimethylaminoazobenzene. Yokoyama, S., Kaneko, A., Dempo, K., Chisaka, N., Mori, M., Onoe, T. Cancer Res. (1982) [Pubmed]
  7. Interaction of cycloheximide and diisopropylphosphorofluoridate (DFP) during subchronic administration in rat. Gupta, R.C., Dettbarn, W.D. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  8. Homocysteine inhibits butyrylcholinesterase activity in rat serum. Stefanello, F.M., Zugno, A.I., Wannmacher, C.M., Wajner, M., Wyse, A.T. Metabolic brain disease. (2003) [Pubmed]
  9. The effect of dichlorvos treatment on butyrylcholinesterase activity and lipid metabolism in rats. Lucić, A., Bradamante, V., Radić, B., Peraica, M., Domijan, A.M., Fuchs, R., Stavljenić-Rukavina, A. Arhiv za higijenu rada i toksikologiju. (2002) [Pubmed]
  10. The effect of cycloheximide on butyrylcholinesterase activity in vivo. Lucić, A., Bradamante, V., Radić, B., Peraica, M., Domijan, A.M., Fuchs, R. Arhiv za higijenu rada i toksikologiju. (2002) [Pubmed]
  11. Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase. Robitzki, A., Döll, F., Richter-Landsberg, C., Layer, P.G. Glia (2000) [Pubmed]
  12. Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat. Edwards, J.A., Brimijoin, S. Biochem. Pharmacol. (1983) [Pubmed]
  13. Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats. Ashry, K.M., Abu-Qare, A.W., Saleem, F.R., Hussein, Y.A., Hamza, S.M., Kishk, A.M., Abou-Donia, M.B. Arch. Toxicol. (2002) [Pubmed]
  14. Relationship between plasmatic levels of sarin and cholinesterase inhibition in rats exposed to sarin vapors. Sevelová, L., Bajgar, J., Bielavská, M. Cent. Eur. J. Public Health (2004) [Pubmed]
  15. Acetylcholinesterase and butyrylcholinesterase activity in the atria of the heart of adult albino rats. Slavíková, J., Vlk, J., Hlavicková, V. Physiologia Bohemoslovaca. (1982) [Pubmed]
  16. The role of cholinesterases in rat urinary bladder contractility. Nakahara, T., Kubota, Y., Sakamoto, K., Ishii, K. Urol. Res. (2003) [Pubmed]
  17. Rat butyrylcholinesterase-catalysed hydrolysis of N-alkyl homologues of benzoylcholine. Hrabovská, A., Debouzy, J.C., Froment, M.T., Devínsky, F., Pauliková, I., Masson, P. FEBS J. (2006) [Pubmed]
  18. Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates. Leader, H., Smejkal, R.M., Payne, C.S., Padilla, F.N., Doctor, B.P., Gordon, R.K., Chiang, P.K. J. Med. Chem. (1989) [Pubmed]
  19. Divergent regulation of acetylcholinesterase and butyrylcholinesterase in tissues of the rat. Edwards, J.A., Brimijoin, S. J. Neurochem. (1982) [Pubmed]
  20. Effects of chronic metrifonate treatment on cholinergic enzymes and the blood-brain barrier. Rakonczay, Z., Papp, H. Neurochem. Int. (2001) [Pubmed]
  21. Cholinergic systems in muscle and brain in vitamin E-deficient rats. Sung, S.C., Sandberg, P.R., McGeer, E.G. Neurochem. Res. (1978) [Pubmed]
  22. Inhibition of rat platelet 5-hydroxytryptamine uptake by chlorpyrifos and carbaryl. Sachana, M., Flaskos, J., Nikolaidis, E., Hargreaves, A., Alexaki-Tzivanidou, E. Pharmacol. Toxicol. (2001) [Pubmed]
  23. Reciprocal regulation of acetylcholinesterase and butyrylcholinesterase in mammalian skeletal muscle. Berman, H.A., Decker, M.M., Jo, S. Dev. Biol. (1987) [Pubmed]
  24. Changes in the levels and forms of rat plasma cholinesterases during chronic diisopropylphosphorofluoridate intoxication. Traina, M.E., Serpietri, L.A. Biochem. Pharmacol. (1984) [Pubmed]
  25. Electrostatic interactions of the butyrylcholinesterase dimer of mucosal cells of rat intestine with glycosaminoglycans. Sine, J.P., Colas, B. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
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