Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN14520658 5-amino-1-[3,4-dihydroxy-5...

Synonyms: NSC-105823, NSC-117661, CTK1C6430, NSC105823, NSC117661, ...

Xie, B. et al., Ido, Y. et al., Ruderman, N.B. et al., Martínez-Chantar, M.L. et al., Huypens, P. et al.

Ido, Carling, Ruderman,

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Disease relevance of AICA-riboside

Previous reports showed that a transposon-induced PurL- mutant of Sinorhizobium fredii induced pseudonodules on Glycine max and the addition of 5-aminoimidazole-4-carboxamide-riboside or adenine to the plant could not restore the mutant to establish effective symbiosis [1].

High impact information on AICA-riboside

RESULTS: We show here that HGF and 5-aminoimidazole-4-carboxamide-riboside (AICAR), an activator of AMP-activated protein kinase (AMPK), induce the phosphorylation of AMPK in hepatocytes and that SAM blocks this process [2].
AMP-activated protein kinase (AMPK) activity was not diminished; however, incubation with the AMPK activator 5-aminoimidazole-4-carboxamide-riboside increased AMPK activity twofold and completely prevented all of these changes [3].
Addition of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR) also caused a decrease in adiponectin protein expression [4].
Similar changes in ACC, MCD and GPAT were observed following the administration of 5-aminoimidazole 4-carboxamide-riboside (AICAR), further indicating that the exercise-induced alterations in these enzymes were AMPK-mediated [5].

References

Symbiotic abilities of Sinorhizobium fredii with modified expression of purL. Xie, B., Chen, D.S., Zhou, K., Xie, Y.Q., Li, Y.G., Hu, G.Y., Zhou, J.C. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Martínez-Chantar, M.L., Vázquez-Chantada, M., Garnacho, M., Latasa, M.U., Varela-Rey, M., Dotor, J., Santamaria, M., Martínez-Cruz, L.A., Parada, L.A., Lu, S.C., Mato, J.M. Gastroenterology (2006) [Pubmed]
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Ido, Y., Carling, D., Ruderman, N. Diabetes (2002) [Pubmed]
Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. Huypens, P., Quartier, E., Pipeleers, D., Van de Casteele, M. Eur. J. Pharmacol. (2005) [Pubmed]
AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Ruderman, N.B., Park, H., Kaushik, V.K., Dean, D., Constant, S., Prentki, M., Saha, A.K. Acta Physiol. Scand. (2003) [Pubmed]

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