The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Adipoq  -  adiponectin, C1Q and collagen domain...

Mus musculus

Synonyms: 30 kDa adipocyte complement-related protein, 30kDa, ACRP30, APN, Acdc, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Adipoq

  • Cardiac function gradually declined over the course of high-fat feeding, and after 20 weeks of high-fat diet, cardiac dysfunction was associated with mild hyperglycemia, hyperleptinemia, and reduced circulating adiponectin levels [1].
  • We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provokes hyperinsulinemia [2].
  • CLINICAL IMPLICATIONS: The data suggest that adiponectin might play a role in the relationship between obesity and asthma [3].
  • CONCLUSION: Our results indicate that serum adiponectin is reduced during pulmonary allergic reactions and that adiponectin attenuates allergic airway inflammation and airway hyperresponsiveness in mice [3].
  • We are reporting that PRL deficiency does not affect the rate of weight gain, body composition, serum lipids, or adiponectin levels in either sex on any diet [4].
  • APN KO mice are protected from chemically induced colitis; administration of APN restores inflammation [5].
  • Pathologic analyses revealed reduced vascularization of APN null tumors along with increased hypoxia and apoptosis [6].
  • Our observations indicate that CR can promote revascularization in response to tissue ischemia via an AMPK-eNOS-dependent mechanism that is mediated by adiponectin [7].

Psychiatry related information on Adipoq


High impact information on Adipoq


Chemical compound and disease context of Adipoq


Biological context of Adipoq


Anatomical context of Adipoq


Associations of Adipoq with chemical compounds


Physical interactions of Adipoq


Regulatory relationships of Adipoq


Other interactions of Adipoq


Analytical, diagnostic and therapeutic context of Adipoq


  1. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Park, S.Y., Cho, Y.R., Kim, H.J., Higashimori, T., Danton, C., Lee, M.K., Dey, A., Rothermel, B., Kim, Y.B., Kalinowski, A., Russell, K.S., Kim, J.K. Diabetes (2005) [Pubmed]
  2. Nutritional Supplementation With trans-10, cis-12-Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue. Poirier, H., Shapiro, J.S., Kim, R.J., Lazar, M.A. Diabetes (2006) [Pubmed]
  3. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. Shore, S.A., Terry, R.D., Flynt, L., Xu, A., Hug, C. J. Allergy Clin. Immunol. (2006) [Pubmed]
  4. The prolactin-deficient mouse has an unaltered metabolic phenotype. Lapensee, C.R., Horseman, N.D., Tso, P., Brandebourg, T.D., Hugo, E.R., Ben-Jonathan, N. Endocrinology (2006) [Pubmed]
  5. Adiponectin deficiency protects mice from chemically induced colonic inflammation. Fayad, R., Pini, M., Sennello, J.A., Cabay, R.J., Chan, L., Xu, A., Fantuzzi, G. Gastroenterology (2007) [Pubmed]
  6. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Denzel, M.S., Hebbard, L.W., Shostak, G., Shapiro, L., Cardiff, R.D., Ranscht, B. Clin. Cancer Res. (2009) [Pubmed]
  7. Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. Kondo, M., Shibata, R., Miura, R., Shimano, M., Kondo, K., Li, P., Ohashi, T., Kihara, S., Maeda, N., Walsh, K., Ouchi, N., Murohara, T. J. Biol. Chem. (2009) [Pubmed]
  8. The role of the novel adipocyte-derived hormone adiponectin in human disease. Díez, J.J., Iglesias, P. Eur. J. Endocrinol. (2003) [Pubmed]
  9. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Yamauchi, T., Oike, Y., Kamon, J., Waki, H., Komeda, K., Tsuchida, A., Date, Y., Li, M.X., Miki, H., Akanuma, Y., Nagai, R., Kimura, S., Saheki, T., Nakazato, M., Naitoh, T., Yamamura, K., Kadowaki, T. Nat. Genet. (2002) [Pubmed]
  10. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Shibata, R., Sato, K., Pimentel, D.R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., Walsh, K. Nat. Med. (2005) [Pubmed]
  11. Adiponectin Expression is Paradoxically Increased in Gold-thioglucose-induced Obesity. Huypens, P., Quartier, E. Horm. Metab. Res. (2006) [Pubmed]
  12. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. He, W., Barak, Y., Hevener, A., Olson, P., Liao, D., Le, J., Nelson, M., Ong, E., Olefsky, J.M., Evans, R.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  13. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. Kubota, N., Terauchi, Y., Kubota, T., Kumagai, H., Itoh, S., Satoh, H., Yano, W., Ogata, H., Tokuyama, K., Takamoto, I., Mineyama, T., Ishikawa, M., Moroi, M., Sugi, K., Yamauchi, T., Ueki, K., Tobe, K., Noda, T., Nagai, R., Kadowaki, T. J. Biol. Chem. (2006) [Pubmed]
  14. Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Poirier, H., Rouault, C., Clément, L., Niot, I., Monnot, M.C., Guerre-Millo, M., Besnard, P. Diabetologia (2005) [Pubmed]
  15. Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Zhou, Q., Du, J., Hu, Z., Walsh, K., Wang, X.H. Endocrinology (2007) [Pubmed]
  16. Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies. Delaigle, A.M., Senou, M., Guiot, Y., Many, M.C., Brichard, S.M. Diabetologia (2006) [Pubmed]
  17. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., Komuro, R., Ouchi, N., Kihara, S., Tochino, Y., Okutomi, K., Horie, M., Takeda, S., Aoyama, T., Funahashi, T., Matsuzawa, Y. Nat. Med. (2002) [Pubmed]
  18. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Bråkenhielm, E., Veitonmäki, N., Cao, R., Kihara, S., Matsuzawa, Y., Zhivotovsky, B., Funahashi, T., Cao, Y. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Chow, F.Y., Nikolic-Paterson, D.J., Ma, F.Y., Ozols, E., Rollins, B.J., Tesch, G.H. Diabetologia (2007) [Pubmed]
  20. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., Walsh, K. J. Biol. Chem. (2004) [Pubmed]
  21. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Flachs, P., Mohamed-Ali, V., Horakova, O., Rossmeisl, M., Hosseinzadeh-Attar, M.J., Hensler, M., Ruzickova, J., Kopecky, J. Diabetologia (2006) [Pubmed]
  22. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. Nawrocki, A.R., Rajala, M.W., Tomas, E., Pajvani, U.B., Saha, A.K., Trumbauer, M.E., Pang, Z., Chen, A.S., Ruderman, N.B., Chen, H., Rossetti, L., Scherer, P.E. J. Biol. Chem. (2006) [Pubmed]
  23. Changes in adiponectin and inflammatory genes in response to hormonal imbalances in female mice and exacerbation of depot selective visceral adiposity by high-fat diet: implications for insulin resistance. Zhang, H., Chen, X., Aravindakshan, J., Sairam, M.R. Endocrinology (2007) [Pubmed]
  24. Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration. Okamoto, M., Ohara-Imaizumi, M., Kubota, N., Hashimoto, S., Eto, K., Kanno, T., Kubota, T., Wakui, M., Nagai, R., Noda, M., Nagamatsu, S., Kadowaki, T. Diabetologia (2008) [Pubmed]
  25. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Hug, C., Wang, J., Ahmad, N.S., Bogan, J.S., Tsao, T.S., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  26. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Qiang, L., Wang, H., Farmer, S.R. Mol. Cell. Biol. (2007) [Pubmed]
  27. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Wang, Z.V., Schraw, T.D., Kim, J.Y., Khan, T., Rajala, M.W., Follenzi, A., Scherer, P.E. Mol. Cell. Biol. (2007) [Pubmed]
  28. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. Delporte, M.L., El Mkadem, S.A., Quisquater, M., Brichard, S.M. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  29. c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Kim, K.Y., Kim, J.K., Jeon, J.H., Yoon, S.R., Choi, I., Yang, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  30. Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism. Bedi, D., Clarke, K.J., Dennis, J.C., Zhong, Q., Brunson, B.L., Morrison, E.E., Judd, R.L. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  31. Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/EBP alpha-evidence for differential regulation of the aP2 and adiponectin genes. Gustafson, B., Jack, M.M., Cushman, S.W., Smith, U. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  32. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., Terasaka, N., Inaba, T., Funahashi, T., Matsuzawa, Y. Circulation (2002) [Pubmed]
  33. Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity. Kim, K.H., Zhao, L., Moon, Y., Kang, C., Sul, H.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  34. Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. Viengchareun, S., Zennaro, M.C., Pascual-Le Tallec, L., Lombes, M. FEBS Lett. (2002) [Pubmed]
  35. A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Kamon, J., Yamauchi, T., Muto, S., Takekawa, S., Ito, Y., Hada, Y., Ogawa, W., Itai, A., Kasuga, M., Tobe, K., Kadowaki, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  36. Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse. Gui, Y., Silha, J.V., Murphy, L.J. Obes. Res. (2004) [Pubmed]
  37. Adiponectin receptor 2 expression in liver and insulin resistance in db/db mice given a beta3-adrenoceptor agonist. Oana, F., Takeda, H., Matsuzawa, A., Akahane, S., Isaji, M., Akahane, M. Eur. J. Pharmacol. (2005) [Pubmed]
  38. Regulation of adiponectin secretion by endothelin-1. Clarke, K.J., Zhong, Q., Schwartz, D.D., Coleman, E.S., Kemppainen, R.J., Judd, R.L. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
WikiGenes - Universities