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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Wiskostatin     1-(3,6-dibromocarbazol-9-yl)- 3...

Synonyms: AG-E-77430, SureCN5800361, BSPBio_001280, CBDivE_008357, KBioGR_000620, ...
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Disease relevance of Wiskostatin


High impact information on Wiskostatin

  • Here we describe the protocols we use to study WASP proteins, including the methods we use to purify signaling components and the assays we use to quantitatively characterize the biochemical and biophysical properties of WASP, its activation by Cdc42, and its inhibition by the small molecule wiskostatin [2].
  • In kinetic studies wiskostatin appeared to accelerate the initial rate of CFTR endocytosis as well as inhibit its recycling back to the cell surface over longer time periods [3].
  • We report here the identification of wiskostatin, a chemical inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP) [4].

Biological context of Wiskostatin

  • We demonstrate, using surface biotinylation methods, that the steady-state surface CFTR pool in stably transfected BHK cells was dramatically decreased following wiskostatin treatment with a corresponding increase in the amount of intracellular CFTR [3].


  1. Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Ivanov, A.I., Hunt, D., Utech, M., Nusrat, A., Parkos, C.A. Mol. Biol. Cell (2005) [Pubmed]
  2. Biochemical properties and inhibitors of (N-)WASP. Leung, D.W., Morgan, D.M., Rosen, M.K. Meth. Enzymol. (2006) [Pubmed]
  3. CFTR surface expression and chloride currents are decreased by inhibitors of N-WASP and actin polymerization. Ganeshan, R., Nowotarski, K., Di, A., Nelson, D.J., Kirk, K.L. Biochim. Biophys. Acta (2007) [Pubmed]
  4. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Peterson, J.R., Bickford, L.C., Morgan, D., Kim, A.S., Ouerfelli, O., Kirschner, M.W., Rosen, M.K. Nat. Struct. Mol. Biol. (2004) [Pubmed]
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