Gene Review:
WASL - Wiskott-Aldrich syndrome-like
Homo sapiens
Synonyms:
N-WASP, NWASP, Neural Wiskott-Aldrich syndrome protein
Ramesh,
Antón,
Martínez-Quiles,
Geha,
Parsons,
Monypenny,
Ameer-Beg,
Millard,
Machesky,
Peter,
Keppler,
Schiavo,
Watson,
Chernoff,
Zicha,
Vojnovic,
Ng,
Carlier,
Nioche,
Broutin-L'Hermite,
Boujemaa,
Le Clainche,
Egile,
Garbay,
Ducruix,
Sansonetti,
Pantaloni,
Ivanov,
Hunt,
Utech,
Nusrat,
Parkos,
Higgs,
Pollard,
- Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri. Suzuki, T., Miki, H., Takenawa, T., Sasakawa, C. EMBO J. (1998)
- A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Moreau, V., Frischknecht, F., Reckmann, I., Vincentelli, R., Rabut, G., Stewart, D., Way, M. Nat. Cell Biol. (2000)
- Actin-based motility of Burkholderia pseudomallei involves the Arp 2/3 complex, but not N-WASP and Ena/VASP proteins. Breitbach, K., Rottner, K., Klocke, S., Rohde, M., Jenzora, A., Wehland, J., Steinmetz, I. Cell. Microbiol. (2003)
- Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Ward, M.E., Wu, J.Y., Rao, Y. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. Snapper, S.B., Rosen, F.S. Annu. Rev. Immunol. (1999)
- Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Higgs, H.N., Pollard, T.D. Annu. Rev. Biochem. (2001)
- Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Ho, H.Y., Rohatgi, R., Lebensohn, A.M., Le Ma, n.u.l.l., Li, J., Gygi, S.P., Kirschner, M.W. Cell (2004)
- Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Volkman, B.F., Prehoda, K.E., Scott, J.A., Peterson, F.C., Lim, W.A. Cell (2002)
- IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Miki, H., Yamaguchi, H., Suetsugu, S., Takenawa, T. Nature (2000)
- Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri. Mimuro, H., Suzuki, T., Suetsugu, S., Miki, H., Takenawa, T., Sasakawa, C. J. Biol. Chem. (2000)
- Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Ivanov, A.I., Hunt, D., Utech, M., Nusrat, A., Parkos, C.A. Mol. Biol. Cell (2005)
- EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Campellone, K.G., Robbins, D., Leong, J.M. Dev. Cell (2004)
- Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. Park, S.J., Suetsugu, S., Takenawa, T. EMBO J. (2005)
- Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. Benesch, S., Lommel, S., Steffen, A., Stradal, T.E., Scaplehorn, N., Way, M., Wehland, J., Rottner, K. J. Biol. Chem. (2002)
- Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Innocenti, M., Gerboth, S., Rottner, K., Lai, F.P., Hertzog, M., Stradal, T.E., Frittoli, E., Didry, D., Polo, S., Disanza, A., Benesch, S., Di Fiore, P.P., Carlier, M.F., Scita, G. Nat. Cell Biol. (2005)
- Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. Otsuki, M., Itoh, T., Takenawa, T. J. Biol. Chem. (2003)
- The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. Zettl, M., Way, M. Curr. Biol. (2002)
- Waltzing with WASP. Ramesh, N., Antón, I.M., Martínez-Quiles, N., Geha, R.S. Trends Cell Biol. (1999)
- Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Miki, H., Sasaki, T., Takai, Y., Takenawa, T. Nature (1998)
- WASP and N-WASP in human platelets differ in sensitivity to protease calpain. Shcherbina, A., Miki, H., Kenney, D.M., Rosen, F.S., Takenawa, T., Remold-O'Donnell, E. Blood (2001)
- Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Prehoda, K.E., Scott, J.A., Mullins, R.D., Lim, W.A. Science (2000)
- GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex. Carlier, M.F., Nioche, P., Broutin-L'Hermite, I., Boujemaa, R., Le Clainche, C., Egile, C., Garbay, C., Ducruix, A., Sansonetti, P., Pantaloni, D. J. Biol. Chem. (2000)
- The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function. Manchanda, N., Lyubimova, A., Ho, H.Y., James, M.F., Gusella, J.F., Ramesh, N., Snapper, S.B., Ramesh, V. J. Biol. Chem. (2005)
- A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. Jiang, Z.Y., Chawla, A., Bose, A., Way, M., Czech, M.P. J. Biol. Chem. (2002)
- VEGF treatment induces signaling pathways that regulate both actin polymerization and depolymerization. Gong, C., Stoletov, K.V., Terman, B.I. Angiogenesis (2004)
- A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. Kempiak, S.J., Yamaguchi, H., Sarmiento, C., Sidani, M., Ghosh, M., Eddy, R.J., Desmarais, V., Way, M., Condeelis, J., Segall, J.E. J. Biol. Chem. (2005)
- Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. Egile, C., Loisel, T.P., Laurent, V., Li, R., Pantaloni, D., Sansonetti, P.J., Carlier, M.F. J. Cell Biol. (1999)
- IQGAP1 Stimulates Actin Assembly through the N-Wasp-Arp2/3 Pathway. Le Clainche, C., Schlaepfer, D., Ferrari, A., Klingauf, M., Grohmanova, K., Veligodskiy, A., Didry, D., Le, D., Egile, C., Carlier, M.F., Kroschewski, R. J. Biol. Chem. (2007)
- Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum. Chen, X.M., Huang, B.Q., Splinter, P.L., Orth, J.D., Billadeau, D.D., McNiven, M.A., LaRusso, N.F. Infect. Immun. (2004)
- A biomimetic motility assay provides insight into the mechanism of actin-based motility. Wiesner, S., Helfer, E., Didry, D., Ducouret, G., Lafuma, F., Carlier, M.F., Pantaloni, D. J. Cell Biol. (2003)
- Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Parsons, M., Monypenny, J., Ameer-Beg, S.M., Millard, T.H., Machesky, L.M., Peter, M., Keppler, M.D., Schiavo, G., Watson, R., Chernoff, J., Zicha, D., Vojnovic, B., Ng, T. Mol. Cell. Biol. (2005)
- Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization. Kessels, M.M., Qualmann, B. J. Biol. Chem. (2006)