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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AmbotzHAA1210     (2S)-4-methyl-2-methylamino- pentanoic acid

Synonyms: AC1MCSAQ, ANW-74881, KB-58630, CTK1A1168, AKOS006282756, ...
 
 
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High impact information on N-Methylleucine

  • The low affinity of BmCYP-1 for CsA arises from incomplete preorganization of the binding site so that the formation of a hydrogen bond between His132 of BmCYP-1 and N-methylleucine 9 of CsA is associated with a shift in the backbone of approximately 1 A in this region [1].
  • Regioisomeric monohydroxylated cyclosporines (metabolites 1, and 17) and N-demethylcyclosporine (metabolite 21) were the primary metabolites resulting from hydroxylation of the C9-amino-acid 1 and the N-methylleucine 9, and from N-demethylation of the N-methylleucine 4 [2].
  • Transformation processes principally involved hydroxylation at the terminal carbon atom (eta-position) of the C9-amino acid 1 and the gamma-position of the N-methylleucines 4, 6, and 9, as well as N-demethylation of the N-methylleucine 4 [2].
  • The absolute stereochemistry of the N-methylleucine amino acid was shown to be L (2'S) by hydrolysis and comparison with standards [3].
  • Didemnin A was conjugated at the amino terminus of the N-methylleucine residue, via the linkers N-succinimidyl-3-(2-pyridyldithio)-propionate and trans-1,4-maleimidomethyl-cyclohexane carboxylic acid, to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA) [4].

References

  1. Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin A. Ellis, P.J., Carlow, C.K., Ma, D., Kuhn, P. Biochemistry (2000) [Pubmed]
  2. Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites. Maurer, G., Loosli, H.R., Schreier, E., Keller, B. Drug Metab. Dispos. (1984) [Pubmed]
  3. Alternatamides A-D: new bromotryptamine peptide antibiotics from the Atlantic marine bryozoan Amathia alternata. Lee, N.K., Fenical, W., Lindquist, N. J. Nat. Prod. (1997) [Pubmed]
  4. An enzyme immunoassay for determining plasma concentrations of didemnin B. Raybould, T.J., Grothaus, P.G., Simpson, S.B., Bignami, G.S., Lazo, C.B., Newman, R.A. J. Clin. Lab. Anal. (1992) [Pubmed]
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