Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L1HEW 1-(4-methoxyphenyl)prop-2-yn- 1-ol

Synonyms: LS-42987, AKOS006279322, BRN 2089996, 19115-30-1, 1'-Hydroxy-2',3'-dehydroestragole, ...

Wiseman, R.W. et al., Wiseman, R.W. et al., Fennell, T.R. et al.

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Disease relevance of BRN 2089996

Creation of a new Xba I restriction site by an AT----TA transversion at the second position of codon 61 was detected in DNA from primary tumors and NIH 3T3 cells transformed by DNA from 6 of 7 vinyl carbamate- and 5 of 10 1'-hydroxy-2',3'-dehydroestragole-induced hepatomas [1].

High impact information on BRN 2089996

DNA from each of 25 hepatomas, induced by N-hydroxy-2-acetylaminofluorene, vinyl carbamate, or 1'-hydroxy-2',3'-dehydroestragole, containing transforming activity in the NIH 3T3 transfection assay [1].
The acetylenic compounds 1'-hydroxy-2',3'-dehydroestragole and 1'-hydroxy-2',3'-dehydrosafrole were the most potent derivatives studied; they were 5- and 10-fold more potent (based on the average numbers of hepatomas per liver) than the corresponding allylic benzene derivatives [2].
Major role of hepatic sulfotransferase activity in the metabolic activation, DNA adduct formation, and carcinogenicity of 1'-hydroxy-2',3'-dehydroestragole in infant male C57BL/6J x C3H/HeJ F1 mice [3].

References

Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse. Wiseman, R.W., Stowers, S.J., Miller, E.C., Anderson, M.W., Miller, J.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
Structure-activity studies of the hepatocarcinogenicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J x C3H/HeJ F1 mice. Wiseman, R.W., Miller, E.C., Miller, J.A., Liem, A. Cancer Res. (1987) [Pubmed]
Major role of hepatic sulfotransferase activity in the metabolic activation, DNA adduct formation, and carcinogenicity of 1'-hydroxy-2',3'-dehydroestragole in infant male C57BL/6J x C3H/HeJ F1 mice. Fennell, T.R., Wiseman, R.W., Miller, J.A., Miller, E.C. Cancer Res. (1985) [Pubmed]

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