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Chemical Compound Review:

AC1MHSJT 6,7-dimethoxyquinazoline

Synonyms: SureCN241727, AK-31429, LS-140098, VA13770000, 4101-33-1, ...

Chappie, T.A. et al., Matsuno, K. et al.

Matsuno, Seishi, Nakajima, Ichimura, Giese, Yu, Oda, Nomoto, Chappie, Humphrey, Allen, Estep, Fox, Lebel, Liras, Marr, Menniti, Pandit, Schmidt, Tu, Williams, Yang,

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High impact information on VA1377000

From this library emerged an aryl ether pyrrolidyl 6,7-dimethoxyquinazoline series that became the focal point for additional modeling, X-ray, and synthetic efforts toward increasing PDE10A inhibitory potency and selectivity versus PDE3A/B [1].
Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety [2].

References

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors. Chappie, T.A., Humphrey, J.M., Allen, M.P., Estep, K.G., Fox, C.B., Lebel, L.A., Liras, S., Marr, E.S., Menniti, F.S., Pandit, J., Schmidt, C.J., Tu, M., Williams, R.D., Yang, F.V. J. Med. Chem. (2007) [Pubmed]
Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. Matsuno, K., Seishi, T., Nakajima, T., Ichimura, M., Giese, N.A., Yu, J.C., Oda, S., Nomoto, Y. Bioorg. Med. Chem. Lett. (2003) [Pubmed]

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