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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.

Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.[1]

References

  1. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. Matsuno, K., Seishi, T., Nakajima, T., Ichimura, M., Giese, N.A., Yu, J.C., Oda, S., Nomoto, Y. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
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