Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL123405 (13S,14R,17S)-13-methyl- 11,12,14,15,16,17...

Synonyms: SureCN1395880, AC1MHU2C, LS-64744, E 380, 17|A-Equilenol, ...

Zhao, Q. et al.

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Disease relevance of EINECS 215-835-8

Ketosteroids (e.g., 19-nortestosterone) and phenolic steroids (e.g., 17 beta-estradiol and 17 beta-dihydroequilenin), which are potent competitive inhibitors of delta 5-3-ketosteroid isomerase (isomerase, EC 5.3.3.1) of Pseudomonas testosteroni, undergo significant polarization upon binding to the active site of the enzyme [1].

High impact information on EINECS 215-835-8

The UV and fluorescence spectral changes of 17 beta-estradiol and 17 beta-dihydroequilenin in the enzyme-bound complex resemble the spectra of ionized phenolate species in aqueous basic solutions [1].

References

Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase. Zhao, Q., Mildvan, A.S., Talalay, P. Biochemistry (1995) [Pubmed]

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