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Chemical Compound Review

AGN-PC-00HPQQ     17-hydroxy-13-methyl- 2,6,7,8,9,10,11,12,14...

Synonyms: NSC-3351, AG-J-97368, SureCN5021656, NSC3351, Oprea1_842874, ...
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Disease relevance of nandrolone


Psychiatry related information on nandrolone

  • Significant positive changes from baseline in DXA BMC at the lumbar spine were observed over 2 years in the calcitonin group (5.0 +/- 1.9%, mean +/- SE) and in the nandrolone deconate group (4.7 +/- 1.9%) but not in the placebo group (1.1 +/- 2.2%) or the combined therapy group (0.7 +/- 1.8%) [5].
  • Abuse of nandrolone decanoate may thus constitute a risk factor for increased alcohol consumption and defensive aggression [6].

High impact information on nandrolone


Chemical compound and disease context of nandrolone


Biological context of nandrolone

  • To determine if gestagens of two separate classes have differing skeletal actions, we studied the effects of pharmacologic doses of norethisterone acetate (NETA), a 19-nortestosterone, and megestrol acetate (MA), a 17 alpha-hydroxyprogesterone, on bone formation and resorption in intact and in ovariectomized mice [16].
  • We conclude that no substantial improvement of anemia due to marrow failure can be ascribed to nandrolone as given, and that clinical trials in these conditions should be controlled to exclude spontaneous remissions as a cause of apparent improvement [3].
  • The pharmacokinetics of nandrolone in serum and urine were investigated in healthy young men after a single im injection of 50 mg (n = 20), 100 mg (n = 17), or 150 mg (n = 17) nandrolone decanoate [17].
  • The comparative kinetics of NA UER, plasma E(2), and E(2)/T ratio suggest a contribution of the aromatase process to nandrolone biosynthesis in man [18].
  • Nandrolone, an inhibitor of cell growth, abolished the growth-inhibitory effects of glucocorticoids but did not displace 3H-triamcinolone acetonide from its binding sites [19].

Anatomical context of nandrolone

  • Quadriceps muscle cross-sectional area increased in patients who were assigned to exercise (P = 0.01) and to nandrolone (P < 0.0001) in an additive manner [10].
  • Moreover, recombinant 3alpha-hydroxysteroid dehydrogenase (AKR1C9) and osteoblast-derived cell lysate each effectively converted estren to 19-nortestosterone in vitro, and mRNA encoding this enzyme occurs in osteoblasts [20].
  • Interventions included double-blinded weekly nandrolone decanoate (100 mg for women; 200 mg for men) or placebo injections and lower extremity resistance exercise training for 12 wk during hemodialysis sessions three times per week using ankle weights [10].
  • Thirty human immunodeficiency virus-positive men with fewer than 400 CD4 lymphocytes/mm3 were randomly assigned to receive weekly injections of nandrolone alone or in combination with supervised PRT at 80% of the one-repetition maximum three times weekly for 12 weeks [21].
  • Some anabolic-androgenic steroids bound strongly to the AR in skeletal muscle and prostate [ RBAs relative to that of MT: MT greater than 19-nortestosterone ( NorT ; nandrolone) greater than methenolone (17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one) greater than testosterone (T) greater than 1 alpha-methyl-DHT] [22].

Associations of nandrolone with other chemical compounds


Gene context of nandrolone


Analytical, diagnostic and therapeutic context of nandrolone


  1. Azoospermia induced by 19-nortestosterone. Parrott, R.F. Lancet (1984) [Pubmed]
  2. A multicenter trial of antithymocyte globulin in aplastic anemia and related diseases. Young, N., Griffith, P., Brittain, E., Elfenbein, G., Gardner, F., Huang, A., Harmon, D., Hewlett, J., Fay, J., Mangan, K. Blood (1988) [Pubmed]
  3. Randomized study of nandrolone therapy for anemias due to bone marrow failure. Branda, R.F., Amsden, T.W., Jacob, H.S. Arch. Intern. Med. (1977) [Pubmed]
  4. Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection. Gold, J., High, H.A., Li, Y., Michelmore, H., Bodsworth, N.J., Finlayson, R., Furner, V.L., Allen, B.J., Oliver, C.J. AIDS (1996) [Pubmed]
  5. Nandrolone decanoate and intranasal calcitonin as therapy in established osteoporosis. Flicker, L., Hopper, J.L., Larkins, R.G., Lichtenstein, M., Buirski, G., Wark, J.D. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1997) [Pubmed]
  6. Anabolic androgenic steroids affects alcohol intake, defensive behaviors and brain opioid peptides in the rat. Johansson, P., Lindqvist, A., Nyberg, F., Fahlke, C. Pharmacol. Biochem. Behav. (2000) [Pubmed]
  7. Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite. Catlin, D.H., Leder, B.Z., Ahrens, B., Starcevic, B., Hatton, C.K., Green, G.A., Finkelstein, J.S. JAMA (2000) [Pubmed]
  8. Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. Johansen, K.L., Mulligan, K., Schambelan, M. JAMA (1999) [Pubmed]
  9. Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation. Jeng, M.H., Parker, C.J., Jordan, V.C. Cancer Res. (1992) [Pubmed]
  10. Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: A randomized, controlled trial. Johansen, K.L., Painter, P.L., Sakkas, G.K., Gordon, P., Doyle, J., Shubert, T. J. Am. Soc. Nephrol. (2006) [Pubmed]
  11. On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase. Penning, T.M., Westbrook, E.M., Talalay, P. Eur. J. Biochem. (1980) [Pubmed]
  12. The effects of nandrolone, testosterone and their decanoate esters on murine lupus. Verheul, H.A., Stimson, W.H., den Hollander, F.C., Schuurs, A.H. Clin. Exp. Immunol. (1981) [Pubmed]
  13. The effect of intrauterine levonorgestrel use on the expression of c-JUN, oestrogen receptors, progesterone receptors and Ki-67 in human endometrium. Salmi, A., Pakarinen, P., Peltola, A.M., Rutanen, E.M. Mol. Hum. Reprod. (1998) [Pubmed]
  14. Binding of [3H] methyltrienolone (R 1881) in rat prostate and human benign prostatic hypertrophy (BPH). Asselin, J., Labrie, F., Gourdeau, Y., Bonne, C., Raynaud, J.P. Steroids (1976) [Pubmed]
  15. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. Schoonen, W.G., Joosten, J.W., Kloosterboer, H.J. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  16. High-dose gestagens modulate bone resorption and formation and enhance estrogen-induced endosteal bone formation in the ovariectomized mouse. Bain, S.D., Jensen, E., Celino, D.L., Bailey, M.C., Lantry, M.M., Edwards, M.W. J. Bone Miner. Res. (1993) [Pubmed]
  17. Pharmacokinetic evaluation of three different intramuscular doses of nandrolone decanoate: analysis of serum and urine samples in healthy men. Bagchus, W.M., Smeets, J.M., Verheul, H.A., De Jager-Van Der Veen, S.M., Port, A., Geurts, T.B. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  18. Urinary nandrolone metabolites of endogenous origin in man: a confirmation by output regulation under human chorionic gonadotropin stimulation. Reznik, Y., Dehennin, L., Coffin, C., Mahoudeau, J., Leymarie, P. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  19. Corticoids and human skin fibroblasts: intracellular specific binding in relation to growth inhibition. Ponec, M., De Kloet, E.R., Kempenaar, J.A. J. Invest. Dermatol. (1980) [Pubmed]
  20. Estren (4-estren-3alpha,17beta-diol) is a prohormone that regulates both androgenic and estrogenic transcriptional effects through the androgen receptor. Centrella, M., McCarthy, T.L., Chang, W.Z., Labaree, D.C., Hochberg, R.B. Mol. Endocrinol. (2004) [Pubmed]
  21. Effects of pharmacological doses of nandrolone decanoate and progressive resistance training in immunodeficient patients infected with human immunodeficiency virus. Sattler, F.R., Jaque, S.V., Schroeder, E.T., Olson, C., Dube, M.P., Martinez, C., Briggs, W., Horton, R., Azen, S. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  22. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Saartok, T., Dahlberg, E., Gustafsson, J.A. Endocrinology (1984) [Pubmed]
  23. The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor. Couzinet, B., Young, J., Brailly, S., Chanson, P., Thomas, J.L., Schaison, G. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  24. Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes. Kontula, K., Paavonen, T., Luukkainen, T., Andersson, L.C. Biochem. Pharmacol. (1983) [Pubmed]
  25. Combined cardiac effects of cocaine and the anabolic steroid, nandrolone, in the rat. Phillis, B.D., Irvine, R.J., Kennedy, J.A. Eur. J. Pharmacol. (2000) [Pubmed]
  26. Formation and metabolism of 5(10)-estrene-3 beta,17 beta-diol, a novel 19-norandrogen produced by porcine granulosa cells from C19 aromatizable androgens. Khalil, M.W., Chung, N., Morley, P., Glasier, M.A., Armstrong, D.T. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  27. Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types. Bovee, T.F., Helsdingen, R.J., Rietjens, I.M., Keijer, J., Hoogenboom, R.L. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  28. Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens. García-Becerra, R., Borja-Cacho, E., Cooney, A.J., Smith, C.L., Lemus, A.E., Pérez-Palacios, G., Larrea, F. J. Steroid Biochem. Mol. Biol. (2006) [Pubmed]
  29. Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone. Lewis, M.I., Horvitz, G.D., Clemmons, D.R., Fournier, M. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  30. Anabolic steroid treatment increases myofiber damage in mdx mouse muscular dystrophy. Krahn, M.J., Anderson, J.E. J. Neurol. Sci. (1994) [Pubmed]
  31. Steroid-binding and dimerization domains of human sex hormone-binding globulin partially overlap: steroids and Ca2+ stabilize dimer formation. Bocchinfuso, W.P., Hammond, G.L. Biochemistry (1994) [Pubmed]
  32. Reversible azoospermia induced by the anabolic steroid 19-nortestosterone. Schürmeyer, T., Knuth, U.A., Belkien, L., Nieschlag, E. Lancet (1984) [Pubmed]
  33. Effects of nandrolone decanoate and antiresorptive therapy on vertebral density in osteoporotic postmenopausal women. Need, A.G., Horowitz, M., Bridges, A., Morris, H.A., Nordin, B.E. Arch. Intern. Med. (1989) [Pubmed]
  34. Rising plasma levels of 19-nortestosterone throughout pregnancy: determination by radioimmunoassay and validation by gas chromatography-mass spectrometry. Reznik, Y., Herrou, M., Dehennin, L., Lemaire, M., Leymarie, P. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  35. A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment. Storer, T.W., Woodhouse, L.J., Sattler, F., Singh, A.B., Schroeder, E.T., Beck, K., Padero, M., Mac, P., Yarasheski, K.E., Geurts, P., Willemsen, A., Harms, M.K., Bhasin, S. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
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