Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Methyl radical $l^{3}-carbane

Synonyms: CHEBI:29309, CHEBI:29430, CH(.), AC1MHY9J, CH3(.), ...

Lipsky, J.J., Klose, R.J. et al.

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Disease relevance of Methyl

In addition, the in vitro observations presented here and a closer examination of the clinical evidence raise the possibility that MTT-containing antibiotic-induced hypoprothrombinemia may not be a vitamin K reversible phenomenon [1].

High impact information on Methyl

A preincubation of MTT with the microsomes decreased the lag time and increased the extent of inhibition [1].
Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain [2].

Chemical compound and disease context of Methyl

Antibiotics that contain a 1-N-methyl-5-thiotetrazole (MTT) side group have been associated with hypoprothrombinemia [1].

References

Mechanism of the inhibition of the gamma-carboxylation of glutamic acid by N-methylthiotetrazole-containing antibiotics. Lipsky, J.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Klose, R.J., Yamane, K., Bae, Y., Zhang, D., Erdjument-Bromage, H., Tempst, P., Wong, J., Zhang, Y. Nature (2006) [Pubmed]

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