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Chemical Compound Review

Didox     N,3,4-trihydroxybenzamide

Synonyms: CHEMBL367788, CCRIS 7909, AG-K-80229, NSC-324360, LS-27443, ...
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Disease relevance of VF 147


High impact information on VF 147


  1. Drug activity and therapeutic synergism in cancer treatment. Carter, W.H., Wampler, G.L., Stablein, D.M., Campbell, E.D. Cancer Res. (1982) [Pubmed]
  2. Effective use of ribonucleotide reductase inhibitors (Didox and Trimidox) alone or in combination with didanosine (ddI) to suppress disease progression and increase survival in murine acquired immunodeficiency syndrome (MAIDS). Mayhew, C., Oakley, O., Piper, J., Hughes, N.K., Phillips, J., Birch, N.J., Elford, H.L., Gallicchio, V.S. Cell. Mol. Biol. (Noisy-le-grand) (1997) [Pubmed]
  3. Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Inayat, M.S., Chendil, D., Mohiuddin, M., Elford, H.L., Gallicchio, V.S., Ahmed, M.M. Cancer Biol. Ther. (2002) [Pubmed]
  4. Studies on the mechanisms of inhibition of L1210 cell growth by 3,4-dihydroxybenzohydroxamic acid and 3,4-dihydroxybenzamidoxime. Tihan, T., Elford, H.L., Cory, J.G. Adv. Enzyme Regul. (1991) [Pubmed]
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