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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

PubChem19029     2-(methyl-propan-2-yloxy...

Synonyms: AG-D-87785, ACMC-20al7q, HSDB 6864, KB-49951, CTK3J3015, ...
 
 
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Disease relevance of Diisopropyl methanephosphonate

 

High impact information on Diisopropyl methanephosphonate

  • It has been reported that the victims were also exposed to the by-products generated during sarin synthesis, i.e., diisopropyl methylphosphonate (DIMP), diethyl methylphosphonate (DEMP) and N,N-diethylaniline (DEA) during the disaster and we previously found that DIMP, DEMP and DEA induced a significant SCE increase in human lymphocytes in vitro [2].
  • We suspected genetic after-effects due to sarin by-products, thus, we checked the frequency of sister chromatid exchange (SCE) and found that SCE was significantly higher in the victims than in a control group, and that DIMP and DEMP significantly induced human lymphocyte SCE in vitro [3].
 

Anatomical context of Diisopropyl methanephosphonate

  • The effect of DIMP and DEMP on the splenic NK activity of mice was stronger than on the splenic CTL activity, and the human lymphocytes is more sensitive to DIMP and DEMP than the splenocytes of mice [3].
 

Analytical, diagnostic and therapeutic context of Diisopropyl methanephosphonate

References

  1. Toxicity of diisopropyl methylphosphonate (DIMP) to aquatic organisms. Burton, D.T., Turley, S.D., Shedd, T.R., Burrows, E.P. Bulletin of environmental contamination and toxicology. (2002) [Pubmed]
  2. Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the event. Li, Q., Hirata, Y., Kawada, T., Minami, M. Toxicology (2004) [Pubmed]
  3. The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity. Li, Q., Hirata, Y., Piao, S., Minami, M. Toxicology (2000) [Pubmed]
  4. Grafted synthetic sorbents for enhanced removal of toxic chemical agents from plasma. McPhillips, D.M., Armer, T.A., Owen, D.R. J. Biomed. Mater. Res. (1983) [Pubmed]
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