Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Monacolin L (4R)-6-[2-[(1S,2R,6R,8aR)- 2,6-dimethyl-1,2...

Synonyms: SureCN12838115, AC1MIW1F, AC1Q29DR, 79394-47-1

Komagata, D. et al., Treiber, L.R. et al.

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Disease relevance of Monacolin L

It seems that all monacolin L found later during various treatments of the broth and broth extracts is formed from that precursor via a dehydration reaction [1].

High impact information on Monacolin L

The producing strain Monascus ruber M 4681 was found to convert exogenously added monacolin L to J. In this hydroxylation reaction 18O2 was incorporated into monacolin L, giving [18O]-monacolin J [2].

Biological context of Monacolin L

The cell-free extracts of M. ruber quantitatively hydroxylated monacolin L to J, and molecular oxygen was required for the hydroxylation [2].

References

Origin of monacolin L from Aspergillus terreus cultures. Treiber, L.R., Reamer, R.A., Rooney, C.S., Ramjit, H.G. J. Antibiot. (1989) [Pubmed]
Biosynthesis of monacolins: conversion of monacolin L to monacolin J by a monooxygenase of Monascus ruber. Komagata, D., Shimada, H., Murakawa, S., Endo, A. J. Antibiot. (1989) [Pubmed]

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