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Chemical Compound Review

Monacolin L     (4R)-6-[2-[(1S,2R,6R,8aR)- 2,6-dimethyl-1,2...

Synonyms: SureCN12838115, AC1MIW1F, AC1Q29DR, 79394-47-1
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Disease relevance of Monacolin L

  • It seems that all monacolin L found later during various treatments of the broth and broth extracts is formed from that precursor via a dehydration reaction [1].

High impact information on Monacolin L


Biological context of Monacolin L

  • The cell-free extracts of M. ruber quantitatively hydroxylated monacolin L to J, and molecular oxygen was required for the hydroxylation [2].


  1. Origin of monacolin L from Aspergillus terreus cultures. Treiber, L.R., Reamer, R.A., Rooney, C.S., Ramjit, H.G. J. Antibiot. (1989) [Pubmed]
  2. Biosynthesis of monacolins: conversion of monacolin L to monacolin J by a monooxygenase of Monascus ruber. Komagata, D., Shimada, H., Murakawa, S., Endo, A. J. Antibiot. (1989) [Pubmed]
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