Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Labdane F2 (1R,2S,4aR,8aR)-2,5,5,8a- tetramethyl-1-(3...

Synonyms: AC1MIW20, 89900-49-2, Ent-8-hydroxylabda-13(16),14-diene

Pang, L. et al., de las Heras, B. et al.

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High impact information on Labdane F2

Surprisingly, under those conditions in which reduced PGE2 generation was observed, labdane F2 consistently enhanced the release of labelled fatty acid, in a manner similar to that displayed by thimerosal a known acyl-CoA: lysolecithin transferase inhibitor [1].
It was also found that nontoxic concentrations of labdane F2 reduced the expression of the inducible isoforms of cyclooxygenase and nitric oxide synthase in LPS-treated J774 cells [1].
Labdane F2 was more potent (approximate IC50 = 3 microM in zymosan-activated macrophages) [2].

References

A novel diterpenoid labdane from Sideritis javalambrensis inhibits eicosanoid generation from stimulated macrophages but enhances arachidonate release. Pang, L., de las Heras, B., Hoult, J.R. Biochem. Pharmacol. (1996) [Pubmed]
Non-cytotoxic inhibition of macrophage eicosanoid biosynthesis and effects on leukocyte functions and reactive oxygen species of two novel anti-inflammatory plant diterpenoids. de las Heras, B., Hoult, J.R. Planta Med. (1994) [Pubmed]

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