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Chemical Compound Review:

AC1MIWZA [5-(6-aminopurin-9-yl)-2- [[[[3-[2-[2-(2...

Synonyms: 34201-15-5, Chloroacetyl coa, Chloroacetyl coenzyme A, Coenzyme A, chloroacetyl, Coenzyme A, S-(chloroacetate)

Tian, W.X. et al., Kumar, S. et al., Tian, W.X. et al.

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Disease relevance of Chloroacetyl coa

Rat liver fatty acid synthetase. Inactivation of the component enzyme catalysing condensation-CO2 exchange reaction by chloroacetyl CoA [1].

High impact information on Chloroacetyl coa

Moreover, chloroacetyl-CoA prevents the modification of the rapidly reacting essential SH group by DTNB [2].
Inactivation by both reagents follows saturation kinetics, indicating the formation of an E ... I complex (dissociation constants of 0.36 microM for chloroacetyl-CoA and 31 microM for bromopyruvate) prior to alkylation [3].
Affinity labeling of chicken liver fatty acid synthase with chloroacetyl-CoA and bromopyruvate [3].

References

Rat liver fatty acid synthetase. Inactivation of the component enzyme catalysing condensation-CO2 exchange reaction by chloroacetyl CoA. Kumar, S., Opas, E., Alli, P. Biochem. Biophys. Res. Commun. (1980) [Pubmed]
Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver. Inactivation by 5,5'-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme. Tian, W.X., Hsu, R.Y., Wang, Y.S. J. Biol. Chem. (1985) [Pubmed]
Affinity labeling of chicken liver fatty acid synthase with chloroacetyl-CoA and bromopyruvate. Tian, W.X., Wang, Y.S., Hsu, R.Y. Biochim. Biophys. Acta (1989) [Pubmed]

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