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Chemical Compound Review:

Monensin B 4-[9-hydroxy-3-[5-[5-[6- hydroxy-6...

Synonyms: AC1MIYKU, 30485-16-6, 16-Deethyl-16-methylmonensin, Monensin, 16-deethyl-16-methyl-

Westley, J.W. et al., Pospísil, S. et al., Liu, H. et al.

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Disease relevance of Monensin B

Isoleucine added to the cultivation medium of Streptomyces cinnamonensis C-100-5 induced a relative increase of the production of monensin B at the expense of monensin A [1].

High impact information on Monensin B

Plasmid (pHL18)-based expression of the S. collinus ccr gene in mutant L1 increased the monensin A/monensin B ratio to 42:58 [2].
By a combination of microanalysis, mass spectrometry and 13C nmr, antibiotics X-14667A and B have been shown to be natural 2-phenethylurethanes of monensin B and A respectively [3].

References

Biosynthesis of monensins A and B: the role of isoleucine. Pospísil, S., Sedmera, P., Krumphanzl, V., Vanĕk, Z. Folia Microbiol. (Praha) (1986) [Pubmed]
Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis. Liu, H., Reynolds, K.A. J. Bacteriol. (1999) [Pubmed]
Isolation of novel antibiotics X-14667A and X-14667B from Streptomyces cinnamonensis subsp. urethanofaciens and their characterization as 2-phenethylurethanes of monensins B and A. Westley, J.W., Evans, R.H., Sello, L.H., Troupe, N., Liu, C., Miller, P.A. J. Antibiot. (1981) [Pubmed]

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