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Chemical Compound Review

Somnium     2-benzhydryloxy-N,N-dimethyl- ethanamine;...

Synonyms: AC1MIZT7, 119177-41-2, Diphenhydramine mixture with lorazepam, Lorazepam mixture with Diphenhydramine
 
 
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Disease relevance of Somnium

  • Previous human pharmacological and toxicological studies demonstrated advantages of the combination drug Somnium [SOM, lorazepam (LOR) 1 mg plus diphenhydramine 25 mg] over 1 mg LOR alone, as it showed synergistic effects in hypnotic properties and antagonistic effects in regard to toxicity [1].
 

High impact information on Somnium

  • Pupillary measures revealed no significant overall inter-drug differences, whereas skin conductance findings demonstrated that the combination drug Somnium was superior to the single component lorazepam also in regard to the anxiolytic effect at the autonomic nervous system level [2].

References

  1. Nonorganic insomnia in generalized anxiety disorder. 2. Comparative studies on sleep, awakening, daytime vigilance and anxiety under lorazepam plus diphenhydramine (Somnium) versus lorazepam alone, utilizing clinical, polysomnographic and EEG mapping methods. Saletu, B., Saletu-Zyhlarz, G., Anderer, P., Brandstätter, N., Frey, R., Gruber, G., Klösch, G., Mandl, M., Grünberger, J., Linzmayer, L. Neuropsychobiology (1997) [Pubmed]
  2. Comparative studies on the effects of the combination drug lorazepam plus diphenhydramine (Somnium) versus lorazepam on the noopsyche, thymopsyche and psychophysiology in nonorganic insomnia related to generalized anxiety disorder. Grünberger, J., Saletu, B., Linzmayer, L., Böck, G., Weissgram, S., Brandstaätter, N., Frey, R., Saletu-Zyhlarz, G. Methods and findings in experimental and clinical pharmacology. (1997) [Pubmed]
 
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