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Chemical Compound Review: 

Leptophoxon     1-bromo-2,5-dichloro-4- (methoxy-phenyl...

Synonyms: Leptophosoxon, Leptophos OA, Leptophos oxon, Phosvel oxon, AC1L1ODL, ...
 
 
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Disease relevance of AI3-27872

  • Because of the commercial unavailability and high toxicity of mipafox, which is usually used as the selective inhibitor for assaying NTE, leptophosoxon was used as an alternative to mipafox [1].
 

High impact information on AI3-27872

  • The toxic and teratogenic effects of 4 organophosphorus compounds (phenyl saliginen cyclic phosphate (PSCP), leptophos-oxon (LPTO), tri-o-tolyl phosphate (TOTP), and paraoxon (PXN] were investigated in the embryos of 3 species of frogs [2].
  • Results indicated that the NTE fraction of hen brain microsomal PV-hydrolyzing activity is the same target for either mipafox or leptophosoxon [1].

References

  1. Assay of chicken brain neurotoxic esterase activity using leptophosoxon as the selective neurotoxic inhibitor. Soliman, S.A., Curley, A. Journal of analytical toxicology. (1981) [Pubmed]
  2. The toxic and teratogenic effects of selected organophosphorus compounds on the embryos of three species of amphibians. Fulton, M.H., Chambers, J.E. Toxicol. Lett. (1985) [Pubmed]
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