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Chemical Compound Review:

TMEA ethyl-trimethyl-azanium

Synonyms: Tmea chloride, CHEMBL104897, AG-E-00514, CHEBI:271685, AC1L1QPO, ...

Roseghini, M. et al., Rassendren, F. et al., Reith, M.E. et al.

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High impact information on ethyl-trimethyl-ammonium

For three of the 38 residues (I328C, N333C, T336C), currents evoked by ATP were inhibited by extracellular application of methanethiosulfonates of either charge (ethyltrimethylammonium, ethylsulfonate) suggesting that they lie in the outer vestibule of the pore [1].
In the present work, we compare the abilities of DAT inhibitors and substrates to affect the reaction of Cys-90, Cys-135, and Cys-342 with MTS ethyltrimethylammonium (MTSET) [2].
Extracts of the skin of some amphibians from Australia and Papua New Guinea contained, in addition to the usual 5-hydroxyindolealkylamines and histamine: a. two new, hitherto unknown indolealkylamines, i.e. O-sulphate of bufotenidine and 2-(3-indolyl) ethyltrimethylammonium, a quaternary ammonium base of tryptamine [3].

References

Identification of amino acid residues contributing to the pore of a P2X receptor. Rassendren, F., Buell, G., Newbolt, A., North, R.A., Surprenant, A. EMBO J. (1997) [Pubmed]
The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter. Reith, M.E., Berfield, J.L., Wang, L.C., Ferrer, J.V., Javitch, J.A. J. Biol. Chem. (2001) [Pubmed]
New and uncommon indole- and imidazole-alkylamines in skins of amphibians from Australia and Papua New Guinea. Roseghini, M., Endean, R., Temperilli, A. Z. Naturforsch., C, Biosci. (1976) [Pubmed]

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