The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Vestibule

  • Thus, the selectivity filter of the TTX-R Na(+) channels in dorsal root ganglion neurons might be located in or close to a multiion single-file pore segment connected externally to a wide vestibule, a molecular feature probably shared by other voltage-gated cationic channels, such as some Ca(2+) and K(+) channels [1].
  • Infection in the affected organs is characterized by abscess formation while in the brain the process is complicated by the development of hydrocephalus and a pachymeningitis that erodes the petrous temporal and involves the vestibular apparatus [2].
  • Inner ear microcirculatory thrombosis was induced by photochemical reaction between systemic injection of Rose Bengal and irradiation of green light to the cochlea and vestibule [3].
  • We report on a cartilaginous choristoma arising in the upper midline oral vestibule [4].
  • In 17 cases in which CT scans revealed the presence of jugular diverticulum, sensorineural symptoms were evaluated with respect to a reference line, perpendicular to the basal turn of the cochlea and tangent to the vestibule in axial CT scan images [5].

Psychiatry related information on Vestibule


High impact information on Vestibule

  • Histological analysis of these mutants demonstrated that in the vestibule, otogelin is required for the anchoring of the otoconial membranes and cupulae to the neuroepithelia [7].
  • Six contingent aromatic residues line the channel and form a path from the vestibule to the periplasmic outlet [8].
  • Using a combination of the substituted cysteine accessibility method and open channel blockers, we found that the M3 segment forms the core of the extracellular vestibule, including a deep site for trapping blockers [9].
  • Permeation of Ca2+ ions was decreased by mutations in M3C and M4N, but not by mutations in preM1, suggesting a functionally distinct contribution of the segments to the extracellular vestibule of the NMDA receptor channel [10].
  • Because 4AP block was inhibited by tetrapentylammonium, we conclude that determinants of 4AP binding lie in the S6 segment that forms the cytoplasmic vestibule of the pore and that this site may overlap a quaternary ammonium site [11].

Chemical compound and disease context of Vestibule


Biological context of Vestibule


Anatomical context of Vestibule


Associations of Vestibule with chemical compounds

  • For three of the 38 residues (I328C, N333C, T336C), currents evoked by ATP were inhibited by extracellular application of methanethiosulfonates of either charge (ethyltrimethylammonium, ethylsulfonate) suggesting that they lie in the outer vestibule of the pore [22].
  • Comparison of the sequence of BK channels to lower-conductance K+ channels and to a crystallized bacterial K+ channel (MthK) revealed that BK channels have a ring of eight negatively charged glutamate residues at the entrance to the intracellular vestibule [23].
  • The vestibules of adult guinea pigs were lesioned with gentamicin and then treated with perilymphatic infusion of either of two growth factor mixtures (i.e., GF I or GF II) [24].
  • A ring of 12 Asp residues within the external vestibule of the pore is responsible for the binding of Ca2+ that accounts for both pore occlusion and blockage of gating [25].
  • The present study uses patch clamp recording to identify a pore-lining lysine residue, Lys-95, that acts to attract large blocker molecules into this inner vestibule [26].

Gene context of Vestibule

  • Throughout embryonic and adult life, the expression of the otogelin gene as monitored by LacZ inserted into Otog, and the abundance of the protein are greater in the vestibule than in the cochlea [27].
  • However, null mutation of the Hmx3 patterning gene produced only a limited vestibular defect, and did not result in the agenesis of the vestibule [28].
  • Finally, Ala 315 of KCNQ3, a residue located in the inner vestibule after the selectivity filter, plays a critical role in preventing current flow in KCNQ3 homomeric channels, whereas it is permissive in heteromers in combination with Thr at the equivalent 276 position of KCNQ2 [29].
  • Thus, structurally diverse open channel blockers of CFTR appear to share a common molecular mechanism of action that involves interaction with a positively charged amino acid side chain located in the inner vestibule of the pore [26].
  • In addition to the vestibule, in the cochlea, Fgf9 mutation caused defects in the interactions between the Reissner's membrane and the mesenchymal cells, leading to a malformed scala vestibuli [30].

Analytical, diagnostic and therapeutic context of Vestibule


  1. Effect of Na(+) flow on Cd(2+) block of tetrodotoxin-resistant Na(+) channels. Kuo, C.C., Lin, T.J., Hsieh, C.P. J. Gen. Physiol. (2002) [Pubmed]
  2. The pathogenesis of acute systemic candidiasis in a susceptible inbred mouse strain. Papadimitriou, J.M., Ashman, R.B. J. Pathol. (1986) [Pubmed]
  3. Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Hokamura, K., Umemura, K., Nakamura, N., Watanabe, M., Takashima, T., Nakashima, M. Prostaglandins Leukot. Essent. Fatty Acids (1998) [Pubmed]
  4. Cartilaginous choristoma deep in the upper midline oral vestibule. Matsushita, K., Tahara, M., Sato, H., Nakamura, E., Fujiwara, T. The British journal of oral & maxillofacial surgery. (2004) [Pubmed]
  5. Jugular bulb diverticula: clinical and radiologic aspects. Bilgen, C., Kirazli, T., Ogut, F., Totan, S. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2003) [Pubmed]
  6. Implant-supported denture in a patient with Huntington's disease: interdisciplinary aspects. Jackowski, J., Andrich, J., Käppeler, H., Zöllner, A., Jöhren, P., Müller, T. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. (2001) [Pubmed]
  7. Targeted disruption of otog results in deafness and severe imbalance. Simmler, M.C., Cohen-Salmon, M., El-Amraoui, A., Guillaud, L., Benichou, J.C., Petit, C., Panthier, J.J. Nat. Genet. (2000) [Pubmed]
  8. Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Schirmer, T., Keller, T.A., Wang, Y.F., Rosenbusch, J.P. Science (1995) [Pubmed]
  9. Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating. Sobolevsky, A.I., Beck, C., Wollmuth, L.P. Neuron (2002) [Pubmed]
  10. NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines. Beck, C., Wollmuth, L.P., Seeburg, P.H., Sakmann, B., Kuner, T. Neuron (1999) [Pubmed]
  11. Segmental exchanges define 4-aminopyridine binding and the inner mouth of K+ pores. Kirsch, G.E., Shieh, C.C., Drewe, J.A., Vener, D.F., Brown, A.M. Neuron (1993) [Pubmed]
  12. Invasive middle ear cholesterol granuloma involving the basal turn of the cochlea with profound sensorineural hearing loss. Murugasu, E., Yong, T.T., Yoon, C.P. Otol. Neurotol. (2004) [Pubmed]
  13. Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis. Chiamvimonvat, N., Pérez-García, M.T., Ranjan, R., Marban, E., Tomaselli, G.F. Neuron (1996) [Pubmed]
  14. Energetics of glycerol conduction through aquaglyceroporin GlpF. Jensen, M.Ø., Park, S., Tajkhorshid, E., Schulten, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Identification of CRYM as a candidate responsible for nonsyndromic deafness, through cDNA microarray analysis of human cochlear and vestibular tissues. Abe, S., Katagiri, T., Saito-Hisaminato, A., Usami, S., Inoue, Y., Tsunoda, T., Nakamura, Y. Am. J. Hum. Genet. (2003) [Pubmed]
  16. Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters. Guzik, T.J., Bzowska, M., Kasprowicz, A., Czerniawska-Mysik, G., Wójcik, K., Szmyd, D., Adamek-Guzik, T., Pryjma, J. Clin. Exp. Allergy (2005) [Pubmed]
  17. Multidrug-exporting secondary transporters. Murakami, S., Yamaguchi, A. Curr. Opin. Struct. Biol. (2003) [Pubmed]
  18. The CHIP28 water channel visualized in ice by electron crystallography. Mitra, A.K., van Hoek, A.N., Wiener, M.C., Verkman, A.S., Yeager, M. Nat. Struct. Biol. (1995) [Pubmed]
  19. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Robbins, J. Pharmacol. Ther. (2001) [Pubmed]
  20. Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors. Rothlin, C.V., Lioudyno, M.I., Silbering, A.F., Plazas, P.V., Casati, M.E., Katz, E., Guth, P.S., Elgoyhen, A.B. Mol. Pharmacol. (2003) [Pubmed]
  21. Some characteristics of glutamic acid decarboxylase of chick ampullary cristae. Meza, G. J. Neurochem. (1984) [Pubmed]
  22. Identification of amino acid residues contributing to the pore of a P2X receptor. Rassendren, F., Buell, G., Newbolt, A., North, R.A., Surprenant, A. EMBO J. (1997) [Pubmed]
  23. A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Brelidze, T.I., Niu, X., Magleby, K.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  24. Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function. Kopke, R.D., Jackson, R.L., Li, G., Rasmussen, M.D., Hoffer, M.E., Frenz, D.A., Costello, M., Schultheiss, P., Van De Water, T.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  25. Molecular basis of calcium regulation in connexin-32 hemichannels. Gómez-Hernández, J.M., de Miguel, M., Larrosa, B., González, D., Barrio, L.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic fibrosis transmembrane conductance regulator chloride channel pore. Linsdell, P. J. Biol. Chem. (2005) [Pubmed]
  27. Spatiotemporal expression of otogelin in the developing and adult mouse inner ear. El-Amraoui, A., Cohen-Salmon, M., Petit, C., Simmler, M.C. Hear. Res. (2001) [Pubmed]
  28. Genetic patterning of embryonic inner ear development. Represa, J., Frenz, D.A., Van De Water, T.R. Acta Otolaryngol. (2000) [Pubmed]
  29. Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation. Etxeberria, A., Santana-Castro, I., Regalado, M.P., Aivar, P., Villarroel, A. J. Neurosci. (2004) [Pubmed]
  30. Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Pirvola, U., Zhang, X., Mantela, J., Ornitz, D.M., Ylikoski, J. Dev. Biol. (2004) [Pubmed]
  31. A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia. Tesfaigzi, J., Th'ng, J., Hotchkiss, J.A., Harkema, J.R., Wright, P.S. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  32. Magnetic resonance imaging of the cochlea, spiral ganglia and eighth nerve of the guinea pig. Counter, S.A., Bjelke, B., Klason, T., Chen, Z., Borg, E. Neuroreport (1999) [Pubmed]
  33. Localization of chat-like immunoreactivity in the vestibular endorgans of the rat. Kong, W.J., Egg, G., Hussl, B., Spoendlin, H., Schrott-Fischer, A. Hear. Res. (1994) [Pubmed]
  34. Epilarynx: pharynx or larynx? Lefebvre, J.L., Buisset, E., Coche-Dequeant, B., Van, J.T., Prevost, B., Hecquet, B., Demaille, A. Head & neck. (1995) [Pubmed]
WikiGenes - Universities