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Chemical Compound Review:

Glupitel N-[2-[4- (cyclohexylcarbamoylsulfamoyl) phen...

Synonyms: Melizide, Minidiab, Minodiab, Glucotrol, Mindiab, ...

Chung, M. et al., Lee, C.C. et al., Chao, H.R. et al., Klaassen, C.H.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Glydiazinamide

This study was designed to compare the pharmacokinetic and short-term pharmacodynamic profile of extended-release glipizide GITS (Glucotrol XL) given in a dosage of 20 mg once daily with that of immediate-release glipizide (Glucotrol) 10mg twice daily in patients with type II diabetes mellitus [1].
Glipizide ('Glibenese') in maturity-onset diabetes mellitus [2].
The corresponding 2,3,7,8-TCDD toxicity equivalent quotient values calculated by international toxicity equivalent factors (I-TEFs) and those recommended by WHO (WHO-TEFs) were 47.2pgI-TEQ/glipid and 53.4pgWHO-TEQ/glipid, respectively [3].

High impact information on Glydiazinamide

Women who reported being Buddhist (64.3 ng/glipid) had significantly higher indicator PCB concentrations than did those who reported being Taoist (35.3 ng/g lipid) [4].

References

Pharmacokinetics and pharmacodynamics of extended-release glipizide GITS compared with immediate-release glipizide in patients with type II diabetes mellitus. Chung, M., Kourides, I., Canovatchel, W., Sutfin, T., Messig, M., Chaiken, R.L. Journal of clinical pharmacology. (2002) [Pubmed]
Glipizide ('Glibenese') in maturity-onset diabetes mellitus. Klaassen, C.H. Current medical research and opinion. (1979) [Pubmed]
Human PCDD/PCDF levels near a pentachlorophenol contamination site in Tainan, Taiwan. Lee, C.C., Guo, Y.L., Kuei, C.H., Chang, H.Y., Hsu, J.F., Wang, S.T., Liao, P.C. Chemosphere (2006) [Pubmed]
Level of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls (PCDD/Fs, PCBs) in human milk and the input to infant body burden. Chao, H.R., Wang, S.L., Lee, C.C., Yu, H.Y., Lu, Y.K., Päpke, O. Food Chem. Toxicol. (2004) [Pubmed]

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