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Chemical Compound Review

TCDD     2,3,7,8-tetrachlorooxanthrene

Synonyms: Dioksyny, Dioxine, Dioxin, TCDBD, Tetradioxin, ...
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Disease relevance of Tetrachlorodibenzodioxin


Psychiatry related information on Tetrachlorodibenzodioxin


High impact information on Tetrachlorodibenzodioxin

  • The Ahr is also activated by dioxin, one of the most intensively studied environmental contaminants [10].
  • Oocytes microinjected with a Bax promoter-reporter construct show Ahr-dependent transcriptional activation after PAH, but not dioxin, treatment, consistent with findings that dioxin is not cytotoxic to oocytes [10].
  • This study of mortality among workers with occupational exposure to TCDD does not confirm the high relative risks reported for many cancers in previous studies [2].
  • Our findings suggest a novel mechanism by which ER-mediated oestrogen signalling is modulated by a co-regulatory-like function of activated AhR/Arnt, giving rise to adverse oestrogen-related actions of dioxin-type environmental contaminants [11].
  • PER contains a motif of approximately 270 amino acids whose function is unknown (termed PAS) and which is also present in three transcription factors of the basic-helix-loop-helix (bHLH) type, in the D. melanogaster single-minded gene product (SIM), and in both subunits of the mammalian dioxin receptor complex [12].

Chemical compound and disease context of Tetrachlorodibenzodioxin


Biological context of Tetrachlorodibenzodioxin


Anatomical context of Tetrachlorodibenzodioxin


Associations of Tetrachlorodibenzodioxin with other chemical compounds


Gene context of Tetrachlorodibenzodioxin


Analytical, diagnostic and therapeutic context of Tetrachlorodibenzodioxin


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