Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL277900 1-[5-(hydroxymethyl)oxolan-2- yl]pyrimidine...

Synonyms: SureCN10349394, NSC-610384, NSC610384, AC1L777O, AC1Q69DD, ...

Zelphati, O. et al., Sastry, J.K. et al., Hao, Z. et al.

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Disease relevance of NSC610384

2',3'-Dideoxyuridine (ddUrd) exhibits poor if any anti-human immunodeficiency virus (HIV) activity in ATH8 and MT-4 cells [1].
2',3'-Dideoxyuridine (ddU) is ineffective at controlling human immunodeficiency virus type 1 (HIV-1) infection in human T cells, because it is not biotransformed to the active 5'-triphosphate [2].

High impact information on NSC610384

Among the 2',3'-dideoxynucleoside 5'-triphosphates containing a physiological base, 2',3'-dideoxyuridine 5'-triphosphate (ddUTP) has been reported to be among the most powerful inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) in cell-free systems [3].

References

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate. Hao, Z., Cooney, D.A., Farquhar, D., Perno, C.F., Zhang, K., Masood, R., Wilson, Y., Hartman, N.R., Balzarini, J., Johns, D.G. Mol. Pharmacol. (1990) [Pubmed]
Membrane-permeable dideoxyuridine 5'-monophosphate analogue inhibits human immunodeficiency virus infection. Sastry, J.K., Nehete, P.N., Khan, S., Nowak, B.J., Plunkett, W., Arlinghaus, R.B., Farquhar, D. Mol. Pharmacol. (1992) [Pubmed]
Inhibition of HIV-1 replication in cultured cells with phosphorylated dideoxyuridine derivatives encapsulated in immunoliposomes. Zelphati, O., Degols, G., Loughrey, H., Leserman, L., Pompon, A., Puech, F., Maggio, A.F., Imbach, J.L., Gosselin, G. Antiviral Res. (1993) [Pubmed]

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