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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL75978     2-(3,4-dimethoxyphenyl)-5- hydroxy-6,7,8...

Synonyms: SureCN1764120, CHEBI:221771, NSC-618927, AC1L7DFJ, NSC618927, ...
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High impact information on NSC618927

  • We have studied the effect of 5- O-demethylnobiletin ( 1) on both the inflammation of mouse ears induced by repeated application of 12- O-tetradecanoylphorbol 13-acetate (TPA) and the acute mouse paw oedemas induced by carrageenan and phospholipase A (2) (PLA (2)), and determined its activity on 5-lipoxygenase (5-LOX) and elastase release/activity [1].
  • As the first step to find natural compounds with protective action against neurodegeneration in the CNS, we here examined whether six citrus flavonoids, namely nobiletin, 5-demethylnobiletin, tangeretin, sinensetin, 6-demethoxytangeretin, and 6-demethoxynobiletin, stimulated CRE-dependent transcription and induced neurite outgrowth in PC12D cells [2].


  1. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Bas, E., Recio, M.C., Giner, R.M., Máñez, S., Cerdá-Nicolás, M., Ríos, J.L. Planta Med. (2006) [Pubmed]
  2. Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., Ohizumi, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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