Chemical Compound Review:
Nobiletin 2-(3,4-dimethoxyphenyl)- 5,6,7,8...
Synonyms:
CHEMBL76447, S2333_Selleck, SureCN244029, CCRIS 9012, AG-K-18756, ...
- Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. Sato, T., Koike, L., Miyata, Y., Hirata, M., Mimaki, Y., Sashida, Y., Yano, M., Ito, A. Cancer Res. (2002)
- Mechanism of neurotrophic action of nobiletin in PC12D cells. Nagase, H., Yamakuni, T., Matsuzaki, K., Maruyama, Y., Kasahara, J., Hinohara, Y., Kondo, S., Mimaki, Y., Sashida, Y., Tank, A.W., Fukunaga, K., Ohizumi, Y. Biochemistry (2005)
- Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation. Yoshimizu, N., Otani, Y., Saikawa, Y., Kubota, T., Yoshida, M., Furukawa, T., Kumai, K., Kameyama, K., Fujii, M., Yano, M., Sato, T., Ito, A., Kitajima, M. Aliment. Pharmacol. Ther. (2004)
- Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. Tanaka, S., Sato, T., Akimoto, N., Yano, M., Ito, A. Biochem. Pharmacol. (2004)
- Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. Chen, K.H., Weng, M.S., Lin, J.K. Biochem. Pharmacol. (2007)
- Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats. Matsuzaki, K., Yamakuni, T., Hashimoto, M., Haque, A.M., Shido, O., Mimaki, Y., Sashida, Y., Ohizumi, Y. Neurosci. Lett. (2006)
- Pharmacological profile of gastric mucosal protection by marmin and nobiletin from a traditional herbal medicine, Aurantii fructus immaturus. Takase, H., Yamamoto, K., Hirano, H., Saito, Y., Yamashita, A. Jpn. J. Pharmacol. (1994)
- Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Murakami, A., Nakamura, Y., Torikai, K., Tanaka, T., Koshiba, T., Koshimizu, K., Kuwahara, S., Takahashi, Y., Ogawa, K., Yano, M., Tokuda, H., Nishino, H., Mimaki, Y., Sashida, Y., Kitanaka, S., Ohigashi, H. Cancer Res. (2000)
- A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. Ishiwa, J., Sato, T., Mimaki, Y., Sashida, Y., Yano, M., Ito, A. J. Rheumatol. (2000)
- Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. Kandaswami, C., Perkins, E., Soloniuk, D.S., Drzewiecki, G., Middleton, E. Cancer Lett. (1991)
- Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. Buening, M.K., Chang, R.L., Huang, M.T., Fortner, J.G., Wood, A.W., Conney, A.H. Cancer Res. (1981)
- Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on p-glycoprotein-mediated transport of talinolol in caco-2 cells. Mertens-Talcott, S.U., Castro, W.V., Manthey, J.A., Derendorf, H., Butterweck, V. J. Agric. Food Chem. (2007)
- Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats. Kohno, H., Yoshitani, S., Tsukio, Y., Murakami, A., Koshimizu, K., Yano, M., Tokuda, H., Nishino, H., Ohigashi, H., Tanaka, T. Life Sci. (2001)
- Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Lin, N., Sato, T., Takayama, Y., Mimaki, Y., Sashida, Y., Yano, M., Ito, A. Biochem. Pharmacol. (2003)
- Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Lee, W.R., Shen, S.C., Lin, H.Y., Hou, W.C., Yang, L.L., Chen, Y.C. Biochem. Pharmacol. (2002)
- In vitro and in vivo activation of oxidative drug metabolism by flavonoids. Lasker, J.M., Huang, M.T., Conney, A.H. J. Pharmacol. Exp. Ther. (1984)
- Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. Whitman, S.C., Kurowska, E.M., Manthey, J.A., Daugherty, A. Atherosclerosis (2005)
- Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. Li, Y., Wang, E., Patten, C.J., Chen, L., Yang, C.S. Drug Metab. Dispos. (1994)
- Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. Miyata, Y., Sato, T., Yano, M., Ito, A. Mol. Cancer Ther. (2004)
- Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. Nagase, H., Omae, N., Omori, A., Nakagawasai, O., Tadano, T., Yokosuka, A., Sashida, Y., Mimaki, Y., Yamakuni, T., Ohizumi, Y. Biochem. Biophys. Res. Commun. (2005)
- Inhibition of bacterial mutagenesis by Citrus flavonoids. Calomme, M., Pieters, L., Vlietinck, A., Vanden Berghe, D. Planta Med. (1996)
- The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice. Minagawa, A., Otani, Y., Kubota, T., Wada, N., Furukawa, T., Kumai, K., Kameyama, K., Okada, Y., Fujii, M., Yano, M., Sato, T., Ito, A., Kitajima, M. Jpn. J. Cancer Res. (2001)
- Nobiletin: efficient and large quantity isolation from orange peel extract. Li, S., Yu, H., Ho, C.T. Biomed. Chromatogr. (2006)