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Chemical Compound Review

Sinensetin     2-(3,4-dimethoxyphenyl)- 5,6,7-trimethoxy...

Synonyms: CHEMBL226507, SureCN621101, AG-E-86509, CHEBI:479523, MEGxp0_000957, ...
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High impact information on C10186


Biological context of C10186


Associations of C10186 with other chemical compounds


Gene context of C10186

  • Sinensetin reversed the resistance of P-glycoprotein (Pgp)-overexpressing AML-2/D100 to vincristine in a concentration-dependent manner [1].
  • Sinensetin cytotoxicity in AML-2/D100 was not changed by the complete inhibition of Pgp, suggesting that it is not a substrate for Pgp [1].


  1. Reversal of P-glycoprotein-mediated multidrug resistance by 5,6,7,3',4'-pentamethoxyflavone (Sinensetin). Choi, C.H., Sun, K.H., An, C.S., Yoo, J.C., Hahm, K.S., Lee, I.H., Sohng, J.K., Kim, Y.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Quantitation of polymethoxylated flavones in orange juice by high-performance liquid chromatography. Rouseff, R.L., Ting, S.V. J. Chromatogr. (1979) [Pubmed]
  3. Polymethoxylated flavones induce Ca(2+)-mediated apoptosis in breast cancer cells. Sergeev, I.N., Li, S., Colby, J., Ho, C.T., Dushenkov, S. Life Sci. (2006) [Pubmed]
  4. Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on p-glycoprotein-mediated transport of talinolol in caco-2 cells. Mertens-Talcott, S.U., Castro, W.V., Manthey, J.A., Derendorf, H., Butterweck, V. J. Agric. Food Chem. (2007) [Pubmed]
  5. Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China. Lu, Y., Zhang, C., Bucheli, P., Wei, D. Plant foods for human nutrition (Dordrecht, Netherlands) (2006) [Pubmed]
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