Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-005W3H 11,17-dihydroxy-17-(2- hydroxyethanoyl)-10...

Synonyms: SureCN12737556, Ambcb5574481, AC1L1GDW, STL372840, AR-1C0362, ...

Pae, H.O. et al., Salauze, D. et al., Strum, J.M. et al.

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High impact information on 11-Epicortisol

In this study, we examined whether glucocorticoids including dexamethasone (Dex) and hydroxycortisone could diminish the cytotoxic effects of anti-microtubule agents including taxol (paclitaxel), microtubule stabilizing agent, and colchicine, microtubule disrupting agent, on human leukemia HL-60 cells [1].
This test has been adapted to rats, using both in vivo and in vitro treatments, and used to validate drugs, including doxycyclin and gentamicin (with cyclosporin A and hydroxycortisone as controls) at the dose levels used in toxicology studies [2].
The only serum-free defined medium that permitted any significant survival or labeling of the cells contained insulin + hydroxycortisone + prolactin [3].

References

Protective effects of glucocorticoids on taxol-induced cytotoxicity in human leukemia HL-60 cells. Pae, H.O., Yoo, J.C., Choi, B.M., Kim, T.Y., Chung, H.T. Immunopharmacology and immunotoxicology. (1999) [Pubmed]
Lymphoproliferative response to mitogen (ConA) after treatment of rats with gentamicin and doxycyclin: relevance to human therapeutics. Salauze, D., Serre, V., Amelin, L. Drug and chemical toxicology. (1994) [Pubmed]
Human breast epithelium in organ culture: effect of hormones on growth and morphology. Strum, J.M., Hillman, E.A. In vitro. (1981) [Pubmed]

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