Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN27636 [(3R,7R,8S,8aS)-8-[2- [(2S,4S)-4-hydroxy-6...

Synonyms: AG-K-36165, CTK6C7487, AC1L7RH1, NCI60_011226

Ownby, S.E. et al., Koszt??czky, B. et al., Cohen, L.H. et al.

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High impact information on Mevacor

When cells are pretreated with LOV, the ability of both FOH and GGOH to restore protein isoprenylation is time dependent; as the LOV pretreatment time increases, the time required for FOH and GGOH to restore isoprenylation also increases [1].
Treatment of NIH3T3 cells with lovastatin (LOV), an HMG-CoA reductase inhibitor, depletes cells of these derivatives and impairs isoprenylation of RAS and RAS-related proteins [1].
Over a 48-h time span, FOH is unable to maintain RAS isoprenylation in the continuing presence of LOV, whereas GGOH is able to maintain Rap1 isoprenylation in the presence of LOV at all times tested [1].
(4) In contrast, the increase in Lov and 25-HC sensitive cholesterol synthesis were higher in resting, but lower in stimulated HC monocytes than in control cells [2].
A, S, L and C were moderate inhibitors in both cellular systems of CYP3A4 [3].

References

Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. Ownby, S.E., Hohl, R.J. Lipids (2003) [Pubmed]
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia. Koszt??czky, B., F??ris, G., Seres, I., Balogh, Z., F??l??p, P., Koncsos, P., Paragh, G. Neuropeptides (2006) [Pubmed]
Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Cohen, L.H., van Leeuwen, R.E., van Thiel, G.C., van Pelt, J.F., Yap, S.H. Biopharmaceutics & drug disposition. (2000) [Pubmed]

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