Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN376816 2-phenylsulfanylethanamine

Synonyms: AG-E-47451, CHEMBL1159899, ALBB-005184, NSC-203124, NSC-215186, ...

Herman, H.H. et al., DiStefano, V. et al.

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Disease relevance of NSC203124

Low concentrations of PTEA (median effective concentrations of 8.0, 12.0, and 1.3 micrograms PTEA/ml) inhibited the growth of P388 murine lymphoma, L1210 leukemia, and B16 melanoma cells in culture [1].

High impact information on NSC203124

In previous work we established that phenyl-2-aminoethyl sulfide (PAES) and derivatives of this basic structure are novel substrate analogs for the adrenergic synthetic enzyme, dopamine beta-monooxygenase (DBM) [2].
We examined the in vivo effects of infusions of PAES and ring-hydroxylated (HOPAES) and/or alpha-methylated derivatives (MePAES, HOMePAES) and observed antihypertensive activity in SHR with HOPAES and HOMePAES using an indirect blood pressure measuring protocol [2].

References

Phenylthioalkylamines in experimental tumor treatment in mice. DiStefano, V., Evans, I., Myers-Robfogel, M., Estes, J., Godleski, S.A. J. Natl. Cancer Inst. (1983) [Pubmed]
Demonstration of the potent antihypertensive activity of phenyl-2-aminoethyl sulfides. Herman, H.H., Pollock, S.H., Fowler, L.C., May, S.W. J. Cardiovasc. Pharmacol. (1988) [Pubmed]

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