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Gene Review

Dbh  -  dopamine beta-hydroxylase (dopamine beta...

Rattus norvegicus

Synonyms: Dopamine beta-hydroxylase, Dopamine beta-monooxygenase
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Disease relevance of Dbh


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Chemical compound and disease context of Dbh


Biological context of Dbh


Anatomical context of Dbh


Associations of Dbh with chemical compounds

  • The results show that there was no difference in TH mRNA content; however, DBH mRNA levels in areas A1, A2, and C1 of the middle-aged animals did not rise during the surge as was observed in the young animals [25].
  • Ethanol potentiated the normal immobilization-induced increase in adrenomedullary TH, DBH, and PNMT messenger RNA (mRNA) [26].
  • Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats [24].
  • These agonists were more effective than nicotine alone in increasing TH and DBH gene expression and significantly elevated [Ca(2+)](i) for up to 6 h [27].
  • Prolonged cortisol administration failed to alter the mRNA levels of TH, DBH, and NPY in control animals but attenuated the response to stress [28].

Physical interactions of Dbh


Co-localisations of Dbh


Regulatory relationships of Dbh


Other interactions of Dbh


Analytical, diagnostic and therapeutic context of Dbh


  1. Tyrosine hydroxylase, but not dopamine beta-hydroxylase, is increased in rat frontal cortex after traumatic brain injury. Yan, H.Q., Kline, A.E., Ma, X., Hooghe-Peters, E.L., Marion, D.W., Dixon, C.E. Neuroreport (2001) [Pubmed]
  2. Indices of neurotransmitter synthesis and release in aging sympathetic nervous system. Partanen, M., Waller, S.B., London, E.D., Hervonen, A. Neurobiol. Aging (1985) [Pubmed]
  3. Rat dopamine beta-hydroxylase: molecular cloning and characterization of the cDNA and regulation of the mRNA by reserpine. McMahon, A., Geertman, R., Sabban, E.L. J. Neurosci. Res. (1990) [Pubmed]
  4. Birth-related up-regulation of mRNA encoding tyrosine hydroxylase, dopamine beta-hydroxylase, neuropeptide tyrosine, and prepro-enkephalin in rat adrenal medulla is dependent on postnatal oxygenation. Holgert, H., Pequignot, J.M., Lagercrantz, H., Hökfelt, T. Pediatr. Res. (1995) [Pubmed]
  5. Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats. de Lonlay, A., Blouquit, M.F., Valens, M., Chami, N., Edwards, D.A., Gripois, D. J. Auton. Nerv. Syst. (1991) [Pubmed]
  6. Effects of various inhibitors of tyrosine hydroxylase and dopamine beta-hydroxylase on rat self-stimulation after reserpine treatment. Stinus, L., Thierry, A.M., Cardo, B. Psychopharmacologia. (1976) [Pubmed]
  7. Stress-induced increase in urinary isatin excretion in rats: reversal by both dexamethasone and alpha-methyl-P-tyrosine. Tozawa, Y., Ueki, A., Manabe, S., Matsushima, K. Biochem. Pharmacol. (1998) [Pubmed]
  8. Diurnal variations in the motor activity of the rat: effects of inhibitors of the catecholamine synthesis. Lemmer, B., Berger, T. Naunyn Schmiedebergs Arch. Pharmacol. (1978) [Pubmed]
  9. The role of norepinephrine in feeding behavior. Rossi, J., Zolovick, A.J., Davies, R.F., Panksepp, J. Neuroscience and biobehavioral reviews. (1982) [Pubmed]
  10. Elimination of REM sleep rebound in rats by alpha-adrenoreceptor blockers, phentolamine and phenoxybenzamine. Radulovacki, M., Wojcik, W.J., Fornal, C., Miletich, R. Pharmacol. Biochem. Behav. (1980) [Pubmed]
  11. A role for synaptotagmin (p65) in regulated exocytosis. Elferink, L.A., Peterson, M.R., Scheller, R.H. Cell (1993) [Pubmed]
  12. A subpopulation of rat dorsal root ganglion neurones is catecholaminergic. Price, J., Mudge, A.W. Nature (1983) [Pubmed]
  13. Central noradrenergic neurones concentrate 3H-oestradiol. Sar, M., Stumpf, W.E. Nature (1981) [Pubmed]
  14. Immune lesions of noradrenergic neurones in rat central nervous system produced by antibodies to dopamine-beta-hydroxylase. Blessing, W.W., Costa, M., Geffen, L.B., Rush, R.A., Fink, G. Nature (1977) [Pubmed]
  15. Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. van Kammen, D.P., Mann, L.S., Sternberg, D.E., Scheinin, M., Ninan, P.T., Marder, S.R., van Kammen, W.B., Rieder, R.O., Linnoila, M. Science (1983) [Pubmed]
  16. Effect of hydrocortisone on catecholamines and the enzymes synthesizing them in the developing sympathetic ganglion. Eränkö, O., Pickel, V.M., Härkönen, M., Eränko, L., Joh, T.H., Reis, D.J. Histochem. J. (1982) [Pubmed]
  17. Immunocytochemical study of tyrosine hydroxylase and dopamine beta-hydroxylase immunoreactivities in the rat pancreas. Oomori, Y., Iuchi, H., Ishikawa, K., Satoh, Y., Ono, K. Histochemistry (1994) [Pubmed]
  18. Catecholamine-synthesizing enzymes and chromogranin proteins in drug-induced proliferative lesions of the rat adrenal medulla. Tischler, A.S., Ruzicka, L.A., Van Pelt, C.S., Sandusky, G.E. Lab. Invest. (1990) [Pubmed]
  19. Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion. Gauda, E.B., Cooper, R., Akins, P.K., Wu, G. J. Appl. Physiol. (2001) [Pubmed]
  20. Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus. Serova, L., Rivkin, M., Nakashima, A., Sabban, E.L. Neuroendocrinology (2002) [Pubmed]
  21. Retrograde axonal transport of dopamine beta hydroxylase antibodies by neurons in the trigeminal ganglion. Reynolds, A.J., Kaasinen, S.K., Hendry, I.A. Neurochem. Res. (2005) [Pubmed]
  22. Rat medulla oblongata. IV. Topographical distribution of catecholaminergic neurons with quantitative three-dimensional computer reconstruction. Kalia, M., Woodward, D.J., Smith, W.K., Fuxe, K. J. Comp. Neurol. (1985) [Pubmed]
  23. Electron microscopic analysis of tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive innervation of the hypothalamic paraventricular nucleus in the rat. Liposits, Z., Phelix, C., Paull, W.K. Histochemistry (1986) [Pubmed]
  24. Age-associated changes in mRNA levels of Phox2, norepinephrine transporter and dopamine beta-hydroxylase in the locus coeruleus and adrenal glands of rats. Zhu, M.Y., Wang, W.P., Iyo, A.H., Ordway, G.A., Kim, K.S. J. Neurochem. (2005) [Pubmed]
  25. Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge. Temel, S., Lin, W., Lakhlani, S., Jennes, L. Endocrinology (2002) [Pubmed]
  26. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Patterson-Buckendahl, P., Kubovcakova, L., Krizanova, O., Pohorecky, L.A., Kvetnansky, R. Alcohol (2005) [Pubmed]
  27. Involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in PC12 cells. Gueorguiev, V.D., Zeman, R.J., Meyer, E.M., Sabban, E.L. J. Neurochem. (2000) [Pubmed]
  28. Immobilization stress elevates gene expression for catecholamine biosynthetic enzymes and some neuropeptides in rat sympathetic ganglia: effects of adrenocorticotropin and glucocorticoids. Nankova, B., Kvetnansky, R., Hiremagalur, B., Sabban, B., Rusnak, M., Sabban, E.L. Endocrinology (1996) [Pubmed]
  29. Estrogen receptor binding in regions of the rat hypothalamus and preoptic area after inhibition of dopamine-beta-hydroxylase. Brown, T.J., Blaustein, J.D., Hochberg, R.B., MacLusky, N.J. Brain Res. (1991) [Pubmed]
  30. Neurosecretory vesicles can be hybrids of synaptic vesicles and secretory granules. Bauerfeind, R., Jelinek, R., Hellwig, A., Huttner, W.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  31. The GTPase Rab3a is associated with large dense core vesicles in bovine chromaffin cells and rat PC12 cells. Darchen, F., Senyshyn, J., Brondyk, W.H., Taatjes, D.J., Holz, R.W., Henry, J.P., Denizot, J.P., Macara, I.G. J. Cell. Sci. (1995) [Pubmed]
  32. Co-localization of substance P and dopamine beta-hydroxylase with growth-associated protein-43 is lost caudal to a spinal cord transection. Cassam, A.K., Rogers, K.A., Weaver, L.C. Neuroscience (1999) [Pubmed]
  33. Involvement of the noradrenergic afferents from the nucleus tractus solitarii to the supraoptic nucleus in oxytocin release after peripheral cholecystokinin octapeptide in the rat. Onaka, T., Luckman, S.M., Antonijevic, I., Palmer, J.R., Leng, G. Neuroscience (1995) [Pubmed]
  34. Changes in tyrosine hydroxylase and dopamine-beta-hydroxylase activities but not in phenylethanolamine-N-methyltransferase activity within central adrenaline neurons after 6-hydroxydopamine administration. Fety, R., Lambas-Senas, L., Chamba, G., Renaud, B. Biochem. Pharmacol. (1984) [Pubmed]
  35. Tyrosine-hydroxylase-containing vagal afferent neurons in the rat nodose ganglion are independent from neuropeptide-Y-containing populations and project to esophagus and stomach. Kummer, W., Bachmann, S., Neuhuber, W.L., Hänze, J., Lang, R.E. Cell Tissue Res. (1993) [Pubmed]
  36. Bee venom acupoint stimulation increases Fos expression in catecholaminergic neurons in the rat brain. Kwon, Y.B., Han, H.J., Beitz, A.J., Lee, J.H. Mol. Cells (2004) [Pubmed]
  37. Evidence for neurotransmitter plasticity in vivo. II. Immunocytochemical studies of rat sweat gland innervation during development. Landis, S.C., Siegel, R.E., Schwab, M. Dev. Biol. (1988) [Pubmed]
  38. Increase of dopamine beta-hydroxylase immunoreactivity in non-noradrenergic nerves of rat cerebral arteries following long-term sympathectomy. Mione, M.C., Sancesario, G., D'Angelo, V., Bernardi, G. Neurosci. Lett. (1991) [Pubmed]
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